吸烟者转抽加热卷烟的抽吸行为和烟碱暴露

为研究吸烟者转抽加热卷烟后抽吸行为和烟碱暴露水平的变化，招募50名抽吸卷烟的志愿者，分为两组，分别转抽加热卷烟IQOS和国内加热卷烟M。转抽前后通过问卷调查获得志愿者的基线资料，使用CReSS吸烟行为记录仪测试吸烟行为参数，采用HPLC-MS/MS测定志愿者基线和转抽后尿样中的烟碱暴露生物标志物。结果表明:①志愿者转抽加热卷烟后抽吸行为基本保持不变，抽吸容量和抽吸时间均未发生显著性改变，但抽吸间隔明显缩短，两组志愿者抽吸卷烟时抽吸间隔分别为（14.3±8.0）s和（15.3±9.0）s，转抽加热卷烟后抽吸间隔分别为（9.8±8.3）s和（9.7±5.4）s。②转抽后志愿者尿液中烟碱总代谢物和可替宁等烟碱暴露生物标志物的浓度水平也未发生显著性改变。③转抽IQOS后志愿者的抽吸行为与转抽M后的志愿者没有明显差异，两组志愿者尿液中烟碱总代谢物和可替宁的水平也近似。 

Smoking behaviors and nicotine exposure levels of cigarette smokers switched to heated tobacco products

In order to investigate smoking behaviors and nicotine exposure levels of cigarette smokers after switching to using heated tobacco products, 50 volunteers who regularly smoked cigarettes were recruited and randomly divided into two groups, one switched to a heated tobacco product known as IQOS and the other group to a domestic heated tobacco product M. Their general smoking characteristics were collected via questionnaires and their smoking parameters were recorded by a CReSS pocket analyzer. The contents of nicotine exposure biomarker in the volunteers' urine samples before and after switching were determined by HPLC-MS/MS. The results showed that: 1) The smoking behaviors of the smokers were basically unchanged after switching to the heated tobacco products, the puffing volume and duration did not change significantly. However, the puffing interval of the two groups significantly shortened from (14.3±8.0) s and (15.3±9.0) s to (9.8±8.3) s and (9.7±5.4) s, respectively. 2) The contents of total nicotine metabolites and nicotine exposure biomarkers (i.e. cotinine) in the volunteers' urine samples did not change significantly after switching to the heated tobacco products. 3) There was no significant difference of the smoking behaviors between the volunteers switched to IQOS and those to M, and the levels of total nicotine metabolites and cotinine in the urine samples of the two groups were also quite similar.