| 热休克蛋白70在乳腺癌中的表达 |
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| 引用本文： | 朱玲勤,陶秀娟,宋辉.热休克蛋白70在乳腺癌中的表达[J].工业卫生与职业病,2008,34(6). |
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| 作者姓名： | 朱玲勤 陶秀娟 宋辉 |
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| 作者单位： | 宁夏医学院公共卫生学院,宁夏,银川,750004 |
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| 基金项目： | 宁夏回族自治区卫生厅资助项目(W200305] |
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| 摘 要： | 目的 探讨乳腺癌组织中热休克蛋白70(HSP70)表达水平及其临床意义.方法 用免疫印迹法检测47例乳腺癌组织和43例良性乳腺病变组织中HSP70的表达.结果 HSP70在乳腺癌组织中的表达水平(142 582)升高.与良性乳腺病变组织(40 449)相比,差异有统计学意义(P<0.01);乳腺癌HSP70的表达与临床分期、淋巴结是否转移及肿瘤直径有关(P<0.05),而与年龄、月经状况及组织学分型无关(P>0.05).结论 HSP70在乳腺癌组织中存在一定程度的异常表达.提示,在乳腺癌的发病机制中可能发挥一定作用.
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| 关 键 词： | 热应激蛋白70 乳腺癌 |
Expression of Heat Shock Protein 70 in Breast Cancer |
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| ZHU Ling-qin,TAO Xiu-juan,SONG Hui.Expression of Heat Shock Protein 70 in Breast Cancer[J].Industrial Health and Occupational Diseases,2008,34(6). |
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| Authors: | ZHU Ling-qin TAO Xiu-juan SONG Hui |
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| Affiliation: | ZHU Ling-qin,TAO Xiu-juan,SONG Hui(School of Public Health,Ningxia Medical College,Yinchuan 750004 China) |
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| Abstract: | Objective To investigate the expression and significance of HSP70 in breast cancer.Methods Tissue homogenate and western blot were used to determine the level of HSP70.Results HSP70 elevated remarkably(P<0.01)in breast cancer compared with control tissues.Expression of HSP70 in breast cancer correlated with clinical stage,lymph nodes metastasis and diameter of cancer(P<0.05),however,HSP70 had no association with age,state of menses and histological type(P>0.05).Conclusions Expression of HSP70 shows somewhat... |
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| Keywords: | Heat shock proteins 70 Breast cancer |
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