龙血竭结肠定位片包衣处方优化

目的:制备龙血竭结肠定位片,并评价其体外释药情况.方法:制备龙血竭含药片芯,采用HPMC,EC与丙烯酸Ⅱ号树脂等制备龙血竭结肠定位片.单因素试验考察药物释放的影响因素,确立处方组成,采用正交设计对包衣液处方进行优化.结果:最佳包衣处方为溶胀层增重3％,肠溶层增重2％,丙烯酸Ⅱ号树脂与EC比值1∶10,结肠定位片的时滞6h,时滞5h后累积释药达80％.结论:龙血竭结肠定位片在体外具有结肠定位释放的特性,能达到治疗结肠部位疾病的目的.

Optimization for Coating Formulation of Longxuejie Colon-target Tablet

Objective:Longxuejie colon-target tablet were prepared and investigated its in vitro release property.Method:Prepared core tablet containing Dranaena cochinchinensis,this colon-target tablet was prepared by hydroxypropylmethylcellulose,ethylcellulose and polyacrylic resin Ⅱ.Coating formulation was established with investigating drug release by single factor test,and orthogonal design was used to optimized coating formulation.Result: Optimal coating formulation was 3% weight gain of swelling coating layer,2% weight gain of enteric coating layer,polyacrylic resin Ⅱ-ethylcellulose 1∶10,colon-target tablet had a lag time of 6 hours and cumulative release quantity reached to 80% within 5 hours.Conclusion: Longxuejie colon-target tablet had colon-release characteristics,and could achieve the purpose of treatment of colon site disease.