| 男性精神分裂症患者前额叶和丘脑质子波谱分析 |
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| 引用本文： | 甘景梨,段惠峰,杨家明,高存友,张东卫,祝希泉,史振娟,蒋占魁,王志娟,马誉.男性精神分裂症患者前额叶和丘脑质子波谱分析[J].中国医学影像技术,2009,25(7):1152-1155. |
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| 作者姓名： | 甘景梨 段惠峰 杨家明 高存友 张东卫 祝希泉 史振娟 蒋占魁 王志娟 马誉 |
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| 作者单位： | 1. 解放军第91中心医院全军精神疾病防治中心,河南,焦作,454003
2. 解放军第91中心医院影像中心,河南,焦作,454003 |
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| 摘 要： | 目的 探讨男性精神分裂症患者前额叶、丘脑的氢质子磁共振波谱(1H-MRS)的特点.方法 以26例7 d内未使用抗精神病药物及影响脑内乙酰胆碱神经递质药物的男性精神分裂症患者为研究组,以28名正常人为对照组.在入组24 h内两组采用多体素1H-MRS检测前额叶和丘脑生化代谢物N-乙酰基天门冬氨酸(NAA)、胆碱复合物(Cho)与肌酸复合物(Cr),完成NAA/Cr值、Cho/Cr值和NAA/(Cho+Cr)值的计算.结果 与对照组相比,研究组左侧前额叶及左、右侧丘脑NAA/Cr值(分别为1.40±0.34、1.45±0.31和1.51±0.32)均低于对照组(分别为1.69±0.31、1.69±0.23和1.70±0.28),差异有统计学意义(P均<0.05).Cho/Cr值和NAA/(Cho+Cr)值两组间比较差异无统计学意义.结论 男性精神分裂症患者的1H-MRS与正常人存在差异,左侧前额叶及丘脑同时存在神经元的功能和(或)结构异常.
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| 关 键 词： | 精神分裂症 磁共振波谱 前额叶 丘脑 |
| 收稿时间： | 1/7/2009 12:00:00 AM |
| 修稿时间： | 2009/3/17 0:00:00 |
1H-MRS study of prefrontal lobe and thalamus in male patients with schizophrenia |
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| GAN Jing-li,DUAN Hui-feng,YANG Jia-ming,GAO Cun-you,ZHANG Dong-wei,ZHU Xi-quan,SHI Zhen-juan,JIANG Zhan-kui,WANG Zhi-juan and MA Yu.1H-MRS study of prefrontal lobe and thalamus in male patients with schizophrenia[J].Chinese Journal of Medical Imaging Technology,2009,25(7):1152-1155. |
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| Authors: | GAN Jing-li DUAN Hui-feng YANG Jia-ming GAO Cun-you ZHANG Dong-wei ZHU Xi-quan SHI Zhen-juan JIANG Zhan-kui WANG Zhi-juan and MA Yu |
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| Affiliation: | Mental Disease Prevention and Treatment Center of Liberation Army,;Mental Disease Prevention and Treatment Center of Liberation Army,;Department of Radiology, PLA 91st Central Hospital, Jiaozuo 454003, China;Mental Disease Prevention and Treatment Center of Liberation Army,;Mental Disease Prevention and Treatment Center of Liberation Army,;Mental Disease Prevention and Treatment Center of Liberation Army,;Mental Disease Prevention and Treatment Center of Liberation Army,;Department of Radiology, PLA 91st Central Hospital, Jiaozuo 454003, China;Department of Radiology, PLA 91st Central Hospital, Jiaozuo 454003, China;Department of Radiology, PLA 91st Central Hospital, Jiaozuo 454003, China |
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| Abstract: | Objective To identify the metabolite levels in prefrontal lobe and thalamus in patients of schizophrenia with proton magnetic resonance spectroscopy (1H-MRS). Methods Twenty-six schizophrenics with medicine-free for at least 7 d and 28 normal controls were assessed in this study. All subjects underwent examination of multi-voxel 1H-MRS on prefrontal lobe and thalamus within 24 h. The NAA, Cho and Cr were measured and the ratios of NAA/Cr, Cho/Cr and NAA/(Cho+Cr) were determined. Results Compared with the controls, the NAA/Cr ratio of schizophrenics was significantly lower in left prefrontal lobe and bilateral thalamus (all P＜0.05). No statistical difference of NAA/(Cho+Cr) ratio and the Cho/Cr ratio was found between two groups. Conclusion Abnormalities in neuronal function and/or integrity are present at left prefrontal lobe and bilateral thalamus simultaneously in schizophrenics. |
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| Keywords: | Schizophrenia Magnetic resonance spectroscopy Prefrontal lobe Thalamus |
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