| C-erbB-2癌基因蛋白在乳腺肿瘤中的表达及临床意义 |
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| 引用本文： | 董雪茹,赵宏亮.C-erbB-2癌基因蛋白在乳腺肿瘤中的表达及临床意义[J].实用癌症杂志,2020(1):47-49. |
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| 作者姓名： | 董雪茹 赵宏亮 |
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| 作者单位： | 河南科技大学附属许昌市中心医院 |
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| 基金项目： | 2017年河南省科技攻关项目(编号:172102310027) |
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| 摘 要： | 目的探讨C-erbB-2癌基因蛋白在乳腺肿瘤中的表达及临床意义。方法对186例乳腺肿瘤患者进行C-erbB-2癌基因蛋白、ER(雌激素受体)及PR(孕激素受体)检测。结果经研究发现C-erbB-2癌基因蛋白阳性表达细胞主要是癌细胞,在导管内癌、Paget’s病、浸润性导管癌患者中呈C-erbB-2癌基因蛋白高表达,而C-erbB-2癌基因蛋白在浸润性小叶癌患者中阴性表达。结论通过在临床对乳腺肿瘤患者行C-erbB-2癌基因蛋白检测,能够早期确诊乳腺癌并准确鉴别乳腺良恶性病变情况。
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| 关 键 词： | C-ERBB-2癌基因蛋白 乳腺肿瘤 免疫组织化学 |
Expression and Clinical Significance of C-erbB-2 Oncogene Protein in Breast Cancer |
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| DONG Xueru,ZHAO Hongliang.Expression and Clinical Significance of C-erbB-2 Oncogene Protein in Breast Cancer[J].The Practical Journal of Cancer,2020(1):47-49. |
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| Authors: | DONG Xueru ZHAO Hongliang |
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| Affiliation: | (Xuchang Central Hospital Affiliated to Henan University of Science and Technology,Xuchang,461000) |
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| Abstract: | Objective To explore the Expression and clinical significance of C-erbB-2 in breast cancer. Methods 186 patients with breast cancer were detection by C-erbB-2 oncogene protein ER( estrogen receptor) and PR( progesterone receptor). Results Positive expression cells of C-erbB-2 were mainly cancer cells,which was presented high expression of C-erbB-2 in patients with intraductal carcinoma,paget’s disease and invasive ductal carcinoma,but was presented negative expression in patients with invasive lobular carcinoma. Conclusion Clinical detection of C-erbB-2 oncogene protein in patients with breast neoplasms can diagnose early with breast cancer,and accurately identify benign and malignant breast lesions. |
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| Keywords: | C-erb B-2 oncogene protein Breast neoplasms Mmunohistochemistry |
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