生物医用高分子材料的血液相容性研究：抗凝血材料的设计（英文）

背景：对于植入生物活体内的高分子材料,应具有医用功能性和生物相容性。目的：论述抗凝血材料的设计及血液相容性高分子材料的凝血机制。方法：由第一作者检索1953/2011PubMed数据库及万方数据库文献。检索词为＂生物相容性材料,抗凝血材料,生物医用材料,医用高分子材料＂。结果与结论：通常对材料进行表面分子设计,改善表面的亲硫水性、引入带电基团、负载生物活性物质等,以尽量减轻血栓形成来提高材料的血液相容性。然而,表面修饰的方法对血液相容性的改善有限。因此,应用组织工程方法在材料表面原位培养人体内皮细胞使材料内皮化,成为改善血液相容性的重要途径。

Hemocompatibility of biomedical polymeric materials Design of anticoagulant materials

BACKGROUND：Polymeric materials implanted into organism in vivo should have two basic performances：medical function and biocompatibility.OBJECTIVE：To review design of anticoagulant materials and clotting mechanism of hemocompatible polymeric materials.METHODS：A computer-based online search of PubMed database and Wanfang database was performed for articles published from 1953 to 2011 with English Key words ＂biocompatibility,blood compatibility,bio-inert surface,bio-active surface＂ and Chinese key words ＂biocompatibility,anticoagulant materials,biomedical materials,medical polymeric materials＂.RESULTS AND CONCLUSION：the material surface is designed to improve surface hydrophilicity and hydrophobicity and to enhance hemocompatibility by reducing thrombosis through introduction of charged groups and bioactive substance.However,effects of surface modification to improve hemocompatibility are limited.Tissue engineering technique enables in situ culture of human endothelial cells on material surface to endothelialize the materials and improve hemocompatibility.