乳腺浸润性导管癌中Paxillin和Caspase-3蛋白的表达及临床意义

  目的  探讨桩蛋白（Paxillin）和天冬氨酸特异性半胱氨酸蛋白酶-3（Caspase-3）在乳腺浸润性导管癌（IDC）中的表达及其与乳腺浸润性导管癌（IDC）患者临床病理因素的关系。   方法  采用免疫组化检测术中切除的原发性乳腺浸润性导管癌（IDC）和距癌灶约5 cm处正常乳腺组织中Paxillin和Caspase-3的表达，统计学分析两者间及其与乳腺浸润性导管癌（IDC）病理特征的关系。   结果  Paxillin在IDC组的表达高于正常乳腺组织组，差异具有统计学意义（P < 0.05）；Caspase-3在IDC组的表达低于正常乳腺组织组，差异具有统计学意义（P < 0.05）。在IDC组中，Paxillin的表达与Her-2状态相关，2种蛋白的表达与乳腺IDC的淋巴结转移及组织学分级相关，2种蛋白在IDC中的表达呈负相关（r=-0.32，P=0.013）。   结论  Paxillin和Caspase-3的的异常表达在乳腺浸润性导管癌（IDC）的发生、发展中可能起着重要的作用，且与乳腺浸润性导管癌（IDC）的浸润转移密切相关。 

Expression and Clinical Significance of Paxillin and Caspase-3 in Breast Invasive Ductal Carcinoma

  Objective  To explore the expression and clinical significance of paxillin and caspase-3 in breast invasive ductal carcinoma (IDC).   Methods  The paxillin and caspase-3 expression in IDC tissue and normal mammary specimens were detected by immunohistochemistry. Then, the correlation between the expression of these two proteins and the clinicopathologic characteristics of breast IDC was analyzed.   Results  The paxillin expression was significantly higher in IDC tissue than in normal mammary tissue (P < 0.05), whereas the caspase-3 expression was significantly lower in IDC tissue than in normal mammary tissue (P < 0.05). In IDC, the paxillin expression was correlated with the Her-2 level, whereas the paxillin and caspase-3 expression was closely correlated with the lymph-node metastasis and histological grades (P < 0.05). Moreover, negative correlations were observed between the paxillin and caspase-3 expression (r = -0.32; P = 0.013).   Conclusion  The abnormal expression of paxillin and caspase-3 plays important roles roles in the occurrence and development of IDC and correlates with the invasion and metastasis of breast IDC.