连续加速超分割和后程加速超分割放射治疗食管癌长期生活质量评定

目的：比较连续加速超分割（CAHF）和后程加速超分割（LCAF）放射治疗食管癌对食管癌患者长期生存质量的影响。方法：运用食管癌放射治疗后常见晚期放射治疗反应主客观处理分析（SOMA）量表、症状自评量表（SCL－90）和生活满意度指数A表（LSI－A）综合评定2个组食管癌放射治疗后生存满3年患者的生活质量包括躯体功能状况、精神心理状态肪自我生活满意度情况。结果：CAHF和LCAF组食管癌长期生存者常见晚期放射反应，SCL－90评分和LSI－A指数无显著差异。结论：（1）运用量表形式评定食管癌放射治疗后生活质量方法可行；（2）初步研究显示CAHF与LCAF方案对食管癌患者长期生活质量影响无显著差别；（3）食管癌患者长期生活质量的评价方法尚需进一步摸索，并需扩大病例数及建立对照样本。

Assessment of long-term quality of life of esophageal carcinoma patients treated with continuous accelerated hyperfractionated and late-course accelerated hyperfractionated radiotherapy

Objective To compare the long term quality of life in esophageal carcinoma patients treated with continuous accelerated hyperfractionated(CAHF) and late course accelerated hyperfractionated (LCAF)radiotherapy. Methods Subjective and Objective Management Analysis (SOMA) scale, Symptom Checklist 90(SCL 90) and Life Satisfaction Index A (LSIA) questionnaire were mailed to the long survivors in both CAHF and LCAF groups to assess the long term quality of life including symptoms, psychological status and life satisfaction. Results There was no significant difference between the two groups in the score of quality of life such as late radiation reaction, SCL 90 and LSI A. Conclusions 1. It is reasonable to assess the quality of life with these scales for esophageal carcinoma patients treated with radiotherapy, 2. Preliminary results demonstrate that there is no significant difference in long term quality of life between the CAHF and LCAF radiotherapy groups, 3. Methods of evaluating the long term quality of life for esophageal carcinoma patients treated with radiotherapy needs further investigation, preferably involving more patients and setting on control arm.