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| 397例急性白血病细胞遗传学与FAB分型相关性研究 | |
| 引用本文： | 霍菲菲,刘欣,孙自敏,朱薇波,郑昌成,汪健,邬志伟.397例急性白血病细胞遗传学与FAB分型相关性研究[J].中国实验血液学杂志,2011,19(1):6-10. |
| 作者姓名： | 霍菲菲 刘欣 孙自敏 朱薇波 郑昌成 汪健 邬志伟 |
| 作者单位： | 1. 安徽医科大学附属省立医院血液科,安徽合肥,230001 2. 安徽医科大学附属省立医院血液病研究室,安徽合肥,230001 3. 安徽医科大学附属省立医院中心实验室,安徽合肥,230001 |
| 摘 要： | 本研究探讨急性白血病的细胞遗传学改变,了解染色体核型异常与急性白血病FAB分型的关系及其对预后因素的影响。397例急性白血病患者于治疗前抽取骨髓标本,采用短期细胞培养法制备染色体标本,应用G显带技术进行染色体核型分析。结果显示,397例急性白血病中78例无分裂相,319例可供染色体核型分析的患者中染色体核型异常175例(占54.9%)。在急性淋巴细胞白血病(ALL)、急性髓系白血病(AML)和急性混合细胞白血病(AMLL)3种类型的白血病患者中,染色体核型异常分别为33/120例(占27.5%)、129/252例(占51.2%)和13/25例(占52.0%)。超二倍体41例(占23.4%),亚二倍体22例(占12.5%),正常二倍体112例(占64.0%)。AML染色体核型异常中与FAB分型相关的特异性染色体重排74/129例(占57.4%)。结论:大约55%左右的急性白血病存在克隆性染色体异常,一些特异性染色体异常改变是急性白血病的细胞遗传学特征,与急性白血病的FAB分型有明显相关性,染色体检查和分子遗传学方法相结合,对于白血病的诊断、分型、治疗和预后都具有重要意义。 |
| 关 键 词： | 急性白血病 染色体 FAB分型 |
Study on Cytogenetic Changes with Relation to FAB Classification in 397 Patients with Acute Leukemias |
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| HUO Fei-Fei,LIU Xin,SUN Zi-Min,ZHU Wei-Bo,ZHENG Chang-Cheng,WANG Jian,WU Zhi-Wei.Study on Cytogenetic Changes with Relation to FAB Classification in 397 Patients with Acute Leukemias[J].Journal of Experimental Hematology,2011,19(1):6-10. | |
| Authors: | HUO Fei-Fei LIU Xin SUN Zi-Min ZHU Wei-Bo ZHENG Chang-Cheng WANG Jian WU Zhi-Wei |
| Affiliation: | HUO Fei-Fei,LIU Xin,SUN Zi-Min,ZHU Wei-Bo,ZHENG Chang-Cheng,WANG Jian1,WU Zhi-Wei2Department of Hematology,1Laboratory of Hematologic Diseases,2Central Laboratory,Provincial Hospital,Anhui Medical University,Hefei 230001,Anhui Province,China |
| Abstract: | The purpose of study was to investigate the cytogenetic abnormality of acute leukemias(AL),to analyze the relationship in the chromosomal abnormality and the AL FAB types,and to explore the impact of the chromosomal abnormalities on the prognostic factors of AL.The chromosome karyotypes of 397 patients with AL were analyzed by means of bone marrow short-term culture and G banding technique.The results showed that in 319 out of 397 patients,the chromosome karyotypes could be analyzed,and the chromosomal abno... |
| Keywords: | acute leukemia chromosome FAB classification |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
