| 二氢杨梅素抗肿瘤活性及其机制的研究进展 |
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| 引用本文： | 周防震,张晓元,郭勇.二氢杨梅素抗肿瘤活性及其机制的研究进展[J].中医药学刊,2010(9):1914-1916. |
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| 作者姓名： | 周防震 张晓元 郭勇 |
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| 作者单位： | [1]华南理工大学生物科学与工程学院,广东广州510006 [2]湖北民族学院生物科学与技术学院,湖北恩施445000 |
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| 基金项目： | 广东省教育部产学研结合项目（2009B090600115） |
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| 摘 要： | 二氢杨梅素是黄酮类化合物之一,大量存在于藤茶植物中,具有多种生理和药理活性。重点介绍它的抗肿瘤活性和4种抗肿瘤作用机制：诱导肿瘤细胞周期阻滞;抑制肿瘤细胞侵袭、转移;抑制肿瘤血管生成;诱导肿瘤细胞凋亡等。认为二氢杨梅素具有作为抗癌药物开发利用的巨大潜力,值得更加深入的研究。
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| 关 键 词： | 二氢杨梅素 抗肿瘤作用 机制 |
Research Progress on Antitumor Effect and Mechanisms of Dihydromyricetin |
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| ZHOU Fang-zhen,ZHANG Xiao-yuan,GUO Yong.Research Progress on Antitumor Effect and Mechanisms of Dihydromyricetin[J].Study Journal of Traditional Chinese Medicine,2010(9):1914-1916. |
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| Authors: | ZHOU Fang-zhen ZHANG Xiao-yuan GUO Yong |
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| Affiliation: | 1. School of Bioscience and Bioengineering, South China University of Technology,Guangzhou 510006, Guangdong,China; 2. School of Biological Science and Technology, Hubei Institute for Nationalities, Enshi 445000, Hubei,China) |
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| Abstract: | Dihydromyricetin, one of flavonoids, was greatly resided in the plant of Ampelopsis grossedentata, with many biological and pharmacological activities. This paper puts the emphasis on the anti-tumor activity and four kinds of anti-tumor mechanisms of dihydromyricetin, including induction of neoplasm cell cycle arrest and cell apoptosis、inhibition of invasion, metastasis and angiogenesis of neoplasm cell. The author holds that dihydromyricetin, possess-ing great potentiality to explore and utilization as a anticancer drug, is worthy of further research. |
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| Keywords: | Dihydromyricetin Anti-tumor effect Mechanism |
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