Plasma protein binding of furosemide in the elderly |
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| Authors: | G M Pacifici A Viani H -U Schulz H -J Frercks |
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| Affiliation: | (1) Department of General Pathology, Medical School, University of Pisa, Pisa, Italy;(2) Department of Geriatrics, Medical University, University of Lübeck, Lübeck, Germany |
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| Abstract: | Summary The protein binding of furosemide was investigated in plasma from 22 old and 11 young subjects by equilibrium dialysis. The unbound fraction of furosemide was 3.16% in plasma from the elderly and 1.71% in plasma from the young. A significant correlation was found between the unbound fraction of furosemide and the plasma concentration of albumin. The average number of binding sites was 3.8 (elderly) and 2.7 (young) 10–6 mol/g albumin. The average association constant (K) was 4.3 (elderly) and 4.2 (young) 105 M–1. By increasing the concentration of furosemide up to 200 µg/ml buffer the unbound fraction of the drug rose to 5.2% (elderly) and 3.5% (young). |
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| Keywords: | furosemide plasma protein binding old age youth |
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