| 高效液相色谱法测定化妆品中苯扎氯铵 |
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| 引用本文： | 张鹏祥,曹蕊,高晓譞,尹家振,张明明,赵华.高效液相色谱法测定化妆品中苯扎氯铵[J].日用化学工业,2012,42(3):230-233. |
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| 作者姓名： | 张鹏祥 曹蕊 高晓譞 尹家振 张明明 赵华 |
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| 作者单位： | 1. 北京工商大学 理学院,北京,1000148
2. 国家食品药品监督管理局 保健食品审评中心,北京,100070 |
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| 基金项目： | 国家食品药品监督管理局专项资助项目 |
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| 摘 要： | 采用高效液相色谱法测定化妆品中苯扎氯铵的含量。色谱条件为:Agilent Zorbax CN柱(250 mm×4.6 mm i.d.,5μm),流动相为V(乙腈)∶V(0.1 mol.L-1醋酸铵缓冲溶液(冰醋酸调pH=5.0))=70∶30的混合溶液,流速1.0 mL.min-1,检测波长260 nm,柱温25℃,进样量20μL。结果表明,该方法的检出限为130μg.g-1,线性范围为5～100 mg.L-1,回收率为92.0%～110.6%,RSD为0.32%～2.10%。
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| 关 键 词： | 化妆品 苯扎氯铵 高效液相色谱法 |
Determination of benzalkonium chloride in cosmetics by high performance liquid chromatography |
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| ZHANG Peng-xiang
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CAO Rui
,
GAO Xiao-xuan
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YIN Jia-zhen
,
ZHANG Ming-ming
,
ZHAO Hua.Determination of benzalkonium chloride in cosmetics by high performance liquid chromatography[J].China Surfactant Detergent & Cosmetics,2012,42(3):230-233. |
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| Authors: | ZHANG Peng-xiang CAO Rui GAO Xiao-xuan YIN Jia-zhen ZHANG Ming-ming ZHAO Hua |
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| Affiliation: | 1(1.School of Science,Beijing Technology and Business University,Beijing 100048,China; 2.The State Food and Drug Administration Center for Health Food Evaluation,Beijing 100070,China) |
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| Abstract: | A high performance liquid chromatographic method was established for the determination of benzalkonium chloride in cosmetics.Chromatography separation was carried out on a Agilent Zorbax CN column(250 mm×4.6 mm i.d.,5 μm),using acetonitrile with 0.1 mol·L-1 ammonium acetate(70∶ 30 volume ratio and pH adjusted to 5.0 by glacial acetic acid) as mobile phase.The flow rate was 1.0 mL·min-1 and the column temperature was 25 ℃.Detection was carried out at 260 nm.The limit of detection is 130 μg·g-1.Linear plot ranges between 5~100 mg·L-1.Average recoveries are 92.0%~110.6% with relative standard deviations of 0.32%~2.10%. |
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| Keywords: | cosmetics benzalkonium chloride high performance liquid chromatography |
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