| 金匮肾气丸对“恐伤肾“大鼠丘脑、海马c-fos基因表达的影响 |
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| 引用本文： | 袁世宏,王米渠,金沈锐.金匮肾气丸对“恐伤肾“大鼠丘脑、海马c-fos基因表达的影响[J].北京中医药大学学报,2001,24(6):34-36,57. |
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| 作者姓名： | 袁世宏 王米渠 金沈锐 |
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| 作者单位： | 1. 山西职工医学院,
2. 成都中医药大学, |
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| 基金项目： | 国家自然科学基金;37950848,39870957; |
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| 摘 要： | 为探讨金匮肾气丸对“恐伤肾“大鼠中枢神经系统丘脑、海马部位c-fos基因表达的影响,采用惊恐刺激大鼠,造成“恐伤肾“动物模型,通过免疫组化方法测定大鼠丘脑、海马c-fos基因表达情况.结果发现惊恐刺激可引起大鼠丘脑、海马c-fos基因表达增高,而金匮肾气丸对这种高表达有控制或降低的作用趋势.提示金匮肾气丸对惊恐刺激大鼠丘脑、海马中c-fos基因表达有控制和降低的作用趋势.
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| 关 键 词： | c-fos基因 恐伤肾 丘脑 海马 金匮肾气丸 大鼠 |
| 修稿时间： | 2000年12月18日 |
Effects of Jinguishenqi Pills on c-fos Gene Expression in the Thalamus and Hippocampus in Rats with TCM Syndrome of the Kidney Being Hurt by Fear |
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| Yuan Shihong,Wang Miqu,Jin Shenrui.Effects of Jinguishenqi Pills on c-fos Gene Expression in the Thalamus and Hippocampus in Rats with TCM Syndrome of the Kidney Being Hurt by Fear[J].Journal of Beijing University of Traditional Chinese Medicine,2001,24(6):34-36,57. |
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| Authors: | Yuan Shihong Wang Miqu Jin Shenrui |
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| Abstract: | The effects of Jinguishenqi Pills (JP) on c fos gene expression in the thalamus and hippocampus were immunohistochemically investigated in the rats with TCM syndrome of the kidney being hurt by fear induced by frightening stimulation. The results showed that frightening stimulation could increase the level of c fos gene expression, and JP exhibited a tendency to control or lower the increased c fos gene expression. |
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| Keywords: | c fos Gene Fear Hurting the Kidney Thalamus Hippocampus Jinguishenqi Pills Rat |
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