基于代谢网络变化的中药整体效应评价方法研究

由于中医的“整体观”和中药复方的复杂非线形特征，采用常规药理指标对中药复方的效应进行评价存在着局限性，而现代医学越来越多地采用系统生物学方法对疾病和药物效应进行研究．使得两个医学体系在整体观和方法学上逐渐走向沟通、互补和融合，为中药复方整体效应评价方法的创新提供了契机。通过研究本文提出了采用系统生物学的策略和方法，基于疾病和药物干预下的系统代谢网络的整体性和动态性的变化评价中药整体效应，从而揭示中医“证”的内涵，解释中药复方对疾病的治疗作用，以及指导中药的安全用药。

Evaluation of Therapeutic Effects of TCM Based on Metabolic Variations

This paper proposes a new methodology to study the response of regulatory network of metabolism,which is helpful for evaluating the basic therapeutic effects of traditional Chinese medicine (TCM),especially in the context of systems biology.Conventional wisdom of pharmacology has proved insufficient in evaluating the therapeutic effects of a multi- herb formula,as TCM formulas are mostly designed in a complicated and non-linear manner,to achieve a coordinated and interactive effect.Western medicine,however,prefers a multi-disciplinary approach to study the mechanism and pathological response of complex diseases to drug therapy.Expecting an enhanced communication,mix,and being com- plementary to one another in both philosophical thinking and methodology,the two medical systems are facing an unprec- edented opportunity for innovation and modernizing TCM.Here one of the systems biology approaches,metabonomics,is employed,to understand the basic dynamic variations of metabolic responses to TCM intervention.This will eventually lead to an improved knowledge of TCM's syndrome theory,therapeutic effects of multi-herb formulas,and the safety of TCM products.