糖尿病视网膜病变患者的中医证候与图形视觉诱发电位的关系

目的]探讨糖尿病视网膜病变（简称糖网症，DR）的中医辨证分型及其与图形视觉诱发电位（P-VEP）的关系。方法]对临床资料完整的104例186眼，按中医辨证分组，分别以不同的空间频率（0.388Hz,1.55Hz)、不同颜色图象组合（黑/白、红/洋红、蓝/青）作刺激条件，检测在100ms检测点上的P-VEP（P100）的潜时（t)和波幅（V）并与正常组作对照。结果]104例186眼中，气阴两虚型有103眼，以单纯性糖网症为主；而气滞血瘀型及阴阳两虚型各有47眼和36眼，均以增殖性糖网症为主，糖网症无论中医辨证分属哪种证候，其P100潜时均延长，波幅均下降，其中以气滞血瘀的潜时延长最为突出，阴阳两虚组的波幅下降最明显，而气阴两虚组的潜时和波幅改变最小。结论]不同中医证候的糖尿病视网膜病变患者的P-VEP的差异有显著性意义。因此，可以认为不同刺激条件的图形视觉诱发电位的检测，有可能为糖尿病视网膜病变的中医辨证分型提供客观指标。

Relationship Between Syndrome Differentiation of Diabetic Retinopathy and Pattern of Visual Evoked Potential

Objective To explore the relationship between syndrome differentiation of diabetic retinopathy (DR) and pattern of visual evoked potential (P-VEP).Methods One hundred and eighty-six eyes from 104 cases of DR were allocated to three groups according to TCM syndrome:qi-yin deficiency (Group A),qi stagnation and blood stasis (Group B) and yin-yang deficiency (Group C).P-VEP induced by various space frequency (0.388?Hz,1.55?Hz) and pictures of various colors (black/white,red/magenta,blue/green) was observed in the three groups and compared with that in the normal control group (Group D).Results One hundred and three eyes in Group A mainly manifested as simple DR,47 eyes in Group B and 36 eyes in Group C mainly manifested as proliferative DR.The latency of P 100 was prolonged and the amplitude was decreassed in all groups of DR,but the latency of P 100 was much prolonged in Group B,the amplitude was much decreased in Group C and the changes were less in Group A.Conclusion P-VEP varies in different TCM syndrome types of DR,and determination of P-VEP under various stimulating conditions may serve as an index of syndrome differentiation of DR.