| 相转移催化法合成7-羟基黄酮的研究 |
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| 引用本文： | 石强,张丽洁,姚转乐,姬明理.相转移催化法合成7-羟基黄酮的研究[J].应用化工,2009,38(10). |
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| 作者姓名： | 石强 张丽洁 姚转乐 姬明理 |
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| 作者单位： | 西安近代化学研究所,陕西,西安,710065 |
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| 摘 要： | 以2,4-二羟基苯乙酮与苯甲酰氯在相转移催化剂四丁基硫酸氢铵催化下,一锅法反应,得到7-羟基黄酮(Ⅲ),产品收率60%,对Ⅲ的反应机理进行了推测,对于Ⅲ质谱表征结果进行了分析。以间苯二酚(Ⅰ)与冰醋酸反应,制得原料2,4-二羟基苯乙酮(Ⅱ),产品收率达到70%。
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| 关 键 词： | 7-羟基黄酮 相转移催化 合成 |
Study on synthesis of 7-hydroxyflavone with phase-transfer catalysis |
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| Abstract: | 7-Hydroxyflavone ( III ) was obtained by means of phase-transfer catalysis from 2,4-di-hydroxyacetophenone and benzoyl chloride using tetrabutylammonium bisulfate as phase transfer catalyst through one-pot reaction. The yield of III was 60%. Mechanism for III formation was proposed,and mass spectrum of HI was resolved. 2,4-Dihydroxyacetophenone ( II ) was also synthesized from resorcinol ( I ) and acetic acid, the yield of II was 70%. |
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| Keywords: | 7-hydroxyflavone phase-transfer catalysis synthesis |
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