| 司他夫定缓释微丸胶囊的制备与体外释放度考察 |
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| 引用本文： | 苏龙,刘志东,吴保祥,聂淑芳,潘卫三.司他夫定缓释微丸胶囊的制备与体外释放度考察[J].中国新药杂志,2007,16(16):1279-1282. |
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| 作者姓名： | 苏龙 刘志东 吴保祥 聂淑芳 潘卫三 |
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| 作者单位： | 1. 沈阳药科大学药学院,沈阳,110016
2. 永信药品工业(昆山)有限公司,昆山,215331 |
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| 摘 要： | 目的:研制司他夫定缓释微丸胶囊。方法:采用溶液法以流化床包衣制备载药微丸,以Kollicoat SR30D为包衣液包覆缓释衣层,制成膜控缓释微丸,考察聚合物增重、后处理方法及致孔剂等因素对缓释微丸释放度的影响。结果:致孔剂可改善缓释微丸的时滞现象,药物释放速度随膜厚及后处理时间的增加而变慢。结论:司他夫定缓释微丸胶囊具有较好的释药性能,是一种较理想的口服缓释制剂。
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| 关 键 词： | 缓释微丸 流化床包衣 司他夫定 体外释放度 |
| 文章编号： | 1003-3734（2007）16-1279-04 |
| 收稿时间： | 2007-06-10 |
| 修稿时间： | 2007年6月10日 |
Preparation and the in vitro release of stavudine extended-release pellets capsules |
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| SU Long,LIU Zhi-dong,WU Bao-xiang,NIE Shu-fang,PAN Wei-san.Preparation and the in vitro release of stavudine extended-release pellets capsules[J].Chinese Journal of New Drugs,2007,16(16):1279-1282. |
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| Authors: | SU Long LIU Zhi-dong WU Bao-xiang NIE Shu-fang PAN Wei-san |
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| Affiliation: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 11 O016, China ; 2 .Yung Shin Pharmaceutics (KS |
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| Abstract: | Objective:To prepare stavudine extended-release pellets capsules.Methods:The fluidized bed coating equipment was used to prepare pellets.Kollicoat SR 30D was used as a sustained-release coating material.The release rate of stavudine from the sustained-release pellets capsules were studied by comparing the increment in coating material weight,the treatment time and the amount of poremaking agent.Results:The poremaking agent improved the lag time of stavudine from the pellets.The release rate was reduced with the increase of thickness in the coating material and treatment time.Conclusions:Stavudine sustained-release pellets capsules show an evident sustained-release effect and may be suitable for oral administration as a sustained-release preparation. |
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| Keywords: | extended-release pellets fluidized bed coating stavudine in vitro release |
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