| 缬沙坦对高血压患者胰岛素抵抗、hs-CRP的疗效 |
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| 引用本文： | 王革新,王大强.缬沙坦对高血压患者胰岛素抵抗、hs-CRP的疗效[J].中国医疗前沿,2012(19):24-25. |
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| 作者姓名： | 王革新 王大强 |
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| 作者单位： | 南阳医学高等专科学校病原生物学及免疫学教研室;南阳医学高等专科学校第一附属医院心血管内科 |
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| 摘 要： | 目的探讨缬沙坦对高血压患者的胰岛素抵抗、hs-CRP的疗效。方法选择98例轻中度原发性高血压患者,随机分为两组,治疗组给予缬沙坦,80mg/d,对照组给予硝苯地平缓释片10mg,2次/d。疗程为12周。在治疗前后测定空腹hs-CRP、血糖、胰岛素水平,用HOMA-IR公式计算胰岛素抵抗指数,比较治疗前后hs-CRP、空腹胰岛素、HOMA-IR变化。结果两组患者治疗12周后,收缩压、舒张压均有显著下降,与治疗前比较其差异有统计学意义（P〈0.01）;缬沙坦组治疗后血清hs-CRP、空腹胰岛素水平、HOMA-IR明显降低,与治疗前比较其差异有统计学意义（P〈0.05）,对照组治疗后hs-CRP、空腹胰岛素水平、HOMA-IR与治疗前比较其差异无统计学意义（P〉0.05）。缬沙坦组治疗后hs-CRP、空腹胰岛素水平、HOMA-IR水平与对照组治疗后比较其差异有统计学意义（P〈0.05）。结论缬沙坦能有效控制血压,降低hs-CRP水平,改善胰岛素抵抗。
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| 关 键 词： | 高血压 缬沙坦 胰岛素抵抗指数 超敏C反应蛋白 |
Effect of Valsartan on High-sensitivity C-reactive Protein and Insulin Resistance in Essential Hypertensive Patients |
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| Abstract: | Objective To investigate the effect of Valsartan on serum high-sensitivity C-reactive protein（hs-CRP） and insulin resistance in hypertensive patients. Methods 98 hypertensive patients were divided into experimental group（Valsartan 80mg, once per day） and control group（nifidipine 10mg twice per day） for twelve weeks for both groups. The level of fasting blood glucose（FBG）, fasting insulin（FINS）, HOMA-IR and hs-CRP were evaluated before and the end of treatment. Results SBP and DBP were significantly reduced in two groups after treatment（P〈0.01）. The level of hs-eRP, FINS and HOMA-IR were significantly decreased in experimental group after treatment（P〈0.05, respectively）. Conclusion Valsartan can reduce hs-CRP and improve insulin resistance in hypertensive patients. |
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| Keywords: | Hypertension Valsartan HOMA-IR hs-CRP |
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