Decrease in ICAM-1 expression on gastric cancer cells is correlated with lymph node metastasis |
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Authors: | Tomofumi Fujihara Masakazu Yashiro Toru Inoue Tetsuji Sawada Yasuyuki Kato Masaichi Ohira Yukio Nishiguchi Tetsuro Ishikawa Michio Sowa Kosei Hirakawa-YS Chung |
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Affiliation: | (1) First Department of Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan, JP;(2) Osaka City General Hospital, 2-13-22 Miyakojima Hondori, Miyakojima-ku, Osaka 534-0021, Japan, JP |
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Abstract: | Background. Lymph node metastasis is a frequent type of metastasis in patients with gastric cancer. The mechanisms responsible for this
type of metastasis, however, are not clearly understood. We hypothesize that the immunosurveillance system between cancer
cells and lymphocytes may be associated with the lymph node metastatic process. In this study, we examined the correlation
between lymph node metastasis and intercellular adhesion molecule-1 (ICAM-1), which mediates the immunosurveillance system
between tumor cells and cytotoxic lymphocytes, in gastric cancer.
Methods. One hundred and forty-three specimens resected from patients with gastric cancer were investigated by staining with a monoclonal
antibody against ICAM-1. We studied the correlation between the expression of ICAM-1 and various clinicopathologic factors,
as well as infiltration of tumor-infiltrating lymphocytes (TILs).
Results. ICAM-1 expression on gastric cancer cells was significantly decreased in patients with lymph node metastasis. The infiltration
of TILs was associated with ICAM-1 expression level. The prognosis of patients with ICAM-1-negative tumors was poorer than
the prognosis of those with ICAM-1-positive tumors.
Conclusions. These findings suggest that ICAM-1 expression on cancer cells is closely associated with lymph node metastasis in gastric
cancer, under the influence of the host immunosurveillance system.
Received on Aug. 20, 1999; accepted on Jan. 5, 2000 |
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Keywords: | : ICAM-1 gastric cancer lymph node metastasis immunosurveillance system TIL |
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