| 基质金属蛋白酶9在胶质瘤中的表达 |
| |
| 引用本文： | 刁宏宇,张明杰,高连波,喻博,李少一,王成林.基质金属蛋白酶9在胶质瘤中的表达[J].中国医科大学学报,2007,36(1):90-92. |
| |
| 作者姓名： | 刁宏宇 张明杰 高连波 喻博 李少一 王成林 |
| |
| 作者单位： | 1. 中国医科大学附属盛京医院神经外科,辽宁,沈阳,110004
2. 辽宁省血栓病中西医结合治疗中心 |
| |
| 摘 要： | 目的:探讨基质金属蛋白酶9(MMP-9)在原发和复发胶质瘤中的表达及改变特点。方法:采用免疫组化法对19例原发、复发脑胶质瘤病人及10例非胶质瘤病人术后的脑组织进行MMP-9检测和比较。结果:胶质瘤复发后,病理级别有增加趋势;MMP-9在脑胶质瘤原发和复发的表达有显著性差异(P<0.01),并与病理分级正相关;胶质瘤复发时间与病理分级相关(P<0.01),而与MMP-9的表达强度之间无统计学意义(P>0.05)。结论:MMP-9在胶质瘤发生、发展过程中起到重要作用,但对于胶质瘤复发速度影响甚小。
|
| 关 键 词： | 胶质瘤 基质金属蛋白酶 侵袭性 |
| 文章编号： | 0258-4646(2007)01-0090-03 |
| 修稿时间： | 2005-12-15 |
Expression of matrix metalloproteinase-9 in human gliomas |
| |
| DIAO Hong-yu,ZHANG Ming-jie,GAO Lian-bo,YU Bo,LI Shao-yi,WANG Cheng-lin.Expression of matrix metalloproteinase-9 in human gliomas[J].Journal of China Medical University,2007,36(1):90-92. |
| |
| Authors: | DIAO Hong-yu ZHANG Ming-jie GAO Lian-bo YU Bo LI Shao-yi WANG Cheng-lin |
| |
| Affiliation: | 1. Department of Neurosurgery,Shengjing Hospital,China Medical University,Shenyang 110004,China; 2. Integrated Traditional Chinese and Western Medicine Thrombus Treatment Center of Liaoning |
| |
| Abstract: | Objective:To study the change in matrix metalloproteinase-9 (MMP-9) expression in primary and recurrent human gliomas. Methods:The expression of MMP-9 in brain tissues was determined immunohistochemically in 19 patients with primary gliomas and subsequent recurrent gliomas and 10 patients without gliomas. Results:The pathological grading of gliomas tended to increase in recurrent gliomas. The expression of MMP-9 in recurrent gliomas was significantly higher than that in primary gliomas (P < 0.01),and it positively correlated with pathological grading. The recurrent time of gliomas was related to the pathological grading,not the expression of MMP-9. Conclusion:MMP-9 may play important roles in the occurrence and development of gliomas,but it has no effect on the recurrence of gliomas. |
| |
| Keywords: | glioma matrix metalloproteinase-9 invasion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
