异体松质骨移植治疗骨肿瘤切除后骨缺损

目的：探讨应用异体松质骨移植治疗肿瘤切除后骨缺损的生物材料填充方法。方法：总结应用深低温冷冻保存异体松质骨移植治疗骨肿瘤切除后骨缺损57例。年龄6－56岁,平均年龄17．4岁。结果：除1例因感染异体骨取出外,其余56例均取得满意的骨愈合,愈合时间平均为4．5个月。依骨腔大小或植骨量的不同愈合时间 亦有所不同。单纯异体松质骨移植与异体松质骨加自体松质骨混合移植相比,愈合时间没有明显不同。植骨量越大,骨愈合时间越长。此组患者中未见明显排异反应及并发感染者。肿瘤复发率为7％。结论：同其他骨缺损填充方法和大块异体骨的使用相比,此种方法可行性较好,安全性较高。在骨愈合率,骨愈合时间上及复发以外并发症的发生上同自体松质骨植骨无明显差异。

Cancellous bone allograft in management of bone defect following tumor resection

Objective To determine whether cancellous bone allograft is the best biological material for filling a cavity bone defect. Methods Between 1992 and 1998, deep frozen cancellous bone allograft was used in the treatment of bone defect in 57 patients following tumor resection. The age of the patients varied from 6 to 56 years (mean 17 4 years). Results Bone unions were achieved in 56 patients, and the average time for union was 4 5 months; One patient had the graft removed for infection. The time for union was different according to the volume of graft. The longer time for union was always accompanied with the larger volume of graft. To compare the union time of admixture of cancellous autograft and allograft with that of cancellous allograft alone,the time for union was same in both group. No immune response and infection was observed in this group. And infection happened in 1 of the 57 patients. The local recurrence rate of tumor was 7%. Conclusions The feasibility and security of this packing method are better than other. Compared with cancellous autograft, no significant difference was found in the time for union and complication rate except local tumor recurrence.