多囊卵巢综合征青年患者血清脂联素、胰岛素抵抗关系的研究

目的探讨多囊卵巢综合征（PCOS）青年患者血清脂联素（APN）、抵抗素（RST）水平与胰岛素抵抗（1R）的关系。方法PCOS组为38例青年PCOS患者，对照组为27例健康女性，两组中根据体重指数（BMI）分为肥胖组BMI（≥25kg／m^2）和非肥胖组（BMI〈25kg／m^2）。在月经第3～5天晨（PCOS闭经者B超检查无优势卵泡当天）留空腹血。采用酶联免疫吸附法（ELISA）测定血清APN和RST浓度，葡萄糖氧化酶法测定血糖浓度，化学发光法测定胰岛素浓度，根据后两者计算胰岛素敏感指数（ISI）。结果（1）肥胖组与非肥胖组空腹血糖水平比较，差异无统计学意义（P〉0．05）;（2）肥胖组与非肥胖组中，PCOS组的空腹胰岛素水平分别显著高于对照组（P〈0．05）；（3）肥胖组中，PCOS组血清APN和ISI水平显著低于对照组，血清RST水平显著高于对照组（P〈0．05）;（4）非肥胖组中，PCOS组血清APN和ISI水平显著低于对照组，血清RST水平显著高于对照组（P〈0．05）。结论（1）与对照组相比，青年PCOS患者血清中APN水平较低，RST水平较高，其中PCOS肥胖患者尤为明显。（2）青年PCOS患者血清中APN水平的下降和RST水平的升高可能与胰岛素敏感性及IR相关。

Study on the relationship of serum adiponectin, resistin and insulin resistance of young patients with polycystic ovary syndrome

Objective：To study the relationship of serum adiponectin （APN）, resistin （RST） and insulin resistance of youth patients with polycystic ovary syndrome （PCOS）.
Methods：Thirty-eight young PCOS patients were studied, with 27 young healthy women as control. The women in each group were subdivided into obesity group and non-obesity group, based on Body Mass Index （BMI）. Serum APN and RST levels of the four groups were detected by enzyme labeled immunosor- bent assay （ELISA）. Blood glucose concentration was detected by glucose oxidase method and insulin con- centration detected by chemiluminescence, and then the insulin sensitivity index （ISI） was calculated.
Results： （1）The fasting blood glucose level of experiment group was similar to that of control （P〉 0.05）. （2） The fasting blood insulin level of experiment group was statistically higher than that of control （P〈0.05）. （3） In obesity group, serum APN level and ISI of PCOS group were statistically lower while serum RST level was statistically higher than those of control group （P〈0. 05）. （4） In non-obesity group, serum APN level and ISI of PCOS group were statistically lower than those of control group, while serum RST level was statistically higher than that of control group （P〈0.05）.
Conclusions. Serum APN level of young PCOS women was lower while serum RST level was higher than that of healthy women, with a tendency of even more dramatic changes in the obese young PCOS women. It is possible that the decrease of serum APN and increase of serum RST in young PCOS patients are related to insulin sensitivity and insulin resistance.