肠道黏液层降解菌Akkermansia muciniphlia和肠道屏障功能关系研究进展

肠道屏障功能异常与肥胖等一系列慢性代谢性疾病相关。Akkermansia muciniphlia是一种肠道黏液层降解菌，与肠道屏障功能关系密切，其丰度在部分代谢性疾病临床病例和动物模型中变化显著，提示该菌可能参与代谢，但具体作用机制有待明确和归纳。本文从A. muciniphlia与肠道黏液层、代谢疾病以及肠道免疫关系这3 个角度，综述了近年来相关研究进展，试图探讨该菌对肠道屏障功能的影响和作用机制，为通过饮食预防慢性代谢疾病提供新的思路。

Recent Advances in the Relationship between Akkermansia muciniphlia and Intestinal Barrier Function

Intestinal barrier dysfunction is associated with some chronic metabolic diseases, such as obesity and diabetes. Akkermansia muciniphlia, a mucin-degrading bacterium that resides in the mucus layer, is closely related to intestinal barrier function. Significant changes in the abundance of this bacterium in clinical cases and some animal models of metabolic diseases suggest its possible involvement in the progression of metabolic diseases. However, the exact mechanism of action remains to be clarified. This article reviews recent advances in the relationship of A. muciniphlia with the intestinal mucus layer, metabolic diseases and intestinal immunity, and also attempts to elucidate the influence and mechanism of action of this bacterium on intestinal barrier function. It is hoped that this review will provide new insights into dietary prevention of chronic metabolic diseases.