老年NIDDM患者微量白蛋白尿与脂质代谢的关系及临床意义

为了研究老年非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者尿微量白蛋白与血脂、脂蛋白的关系，测定了老年ＮＩＤＤＭ伴微量白蛋白尿（ＵＡＥ）患者和ＮＩＤＤＭ不伴ＵＡＥ患者及正常对照组的甘油三酯（ＴＧ）、胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ Ｃ）、高密度脂蛋白胆固醇（ＨＤＬ Ｃ）、载脂蛋白Ａ（ａｐｏＡ）、载脂蛋白Ｂ（ａｐｏＢ）、脂蛋白（ａ）〔ＬＰ（ａ）〕。结果：老年ＮＩＤＤＭ伴有微量蛋白尿患者的ＴＧ、Ｌｐ（ａ）显著高于不伴ＵＡＥ的ＮＩＤＤＭ患者及对照组，而ａｐｏＡ及ＨＤＬ Ｃ明显低于不伴ＵＡＥ的ＮＩＤＤＭ患者及对照组。结果提示：老年ＮＩＤＤＭ伴有微量白蛋白尿患者的心血管病的发病率及死亡率的增加可能与血脂及脂蛋白代谢异常有关。

Serum Lipids and Lipoproteins in Elder NIDDM Patients with Microalbuminuria

To study the relationship of slight albuminuria(microalbuminuria)to serum lipids and lipoproteins in elder NIDDM, the levels of plasma TC、TG、HDL-C、apoA、apoB、Lp(a)were determined in elder NIDDM patients with microalbuminuria and normal albuminuria and control subjects. The result showed that the levels of plasma TG Lp(a)in elder NIDDM patients with microalbuminuria were significantly higher than those in elder NIDDM patients with normal albuminuria and control subjects. The levels of plasma HDL-C、 apoA in elder NIDDM patients with microalbuminuria were significantly lower than those in elder NIDDM patients with normal albuminuria and control subjects. It is conclude that elder NIDDM patients with microalbuminuria are associated with alter lipid and lipoprotein levels. The excess cardiovascular mortality and morbidity in elder NIDDM patients with microalbuminuria may. In part, be explained by these lipidand lipoprotein abnormalities.