2型糖尿病患者病程与四种尿微量蛋白测定水平分析

目的探讨检测尿微量白蛋白（mALB）、β2微球蛋白（β2-MG）、免疫球蛋白（IgG）、视黄醇结合蛋白（RBP）水平与不同病程2型糖尿病患者肾脏损害的相关性及对早期糖尿病肾病的诊断价值。方法选取120例2型糖尿病患者,按病程分组,A组病程1～7年,40例;B组病程8～14年,42例;C组病程15～20年,38例。选取65例体检健康职工为对照组。比较各组对象尿mALB、β2-MG、IgG、RBP水平。结果糖尿病组与对照组比较,尿mALB、β2-MG、IgG、RBP水平均明显升高,且与病程正相关。结论联合检测尿mALB、β2-MG、IgG、RBP对早期糖尿病肾病的诊断及防治具有重要临床意义。

Type 2 diabetes patients with disease duration and the determination of the level of the four kinds of urine trace protein analysis

Objective To investigate the relationship between level of microalbumin albumin （mALB）, β2-microglobulin （β2-MG）, immune globulin （IgG） and retinol binding protein （RBP）and the kidney damage to different duration of type 2 diabetes patients. To investigate evaluation of the diagnostic value of early diabetic nephropathy . Methods One hundred and twenty patients with type 2 diabetes were divided into three groups based on the course of the disease, 40 cases in group A： disease course was 1 to 7 years; 42 cases in group B, disease course was 8 to 14 years; 38 cases in group C, disease course was 15 to 20 years. 65 health workers who take physical examination in our hospital were selected as control group. The urine mALB, β2-MG, IgG, RBP level of each group were compared. Results Compared with control group, diabetic group＇s urine of mALB, β2-MG, IgG and RBP significantly increased, and there was a positive correlation with the disease course. Conclusion The combined determination of urine of mALB, β2-MG, IgG and RBP has important clinical significance in diagnosis and prevention of early diabetic nephropathy.