罗格列酮的胰岛素增敏作用和胰岛素抵抗改善作用

目的　观察罗格列酮的胰岛素增敏作用和胰岛素抵抗改善作用。方法　大鼠尾静脉注射链佐菌素 (5 0mg·kg-1)制备IDDM模型 ,观察单用罗格列酮、单用小剂量胰岛素 (皮下注射 2 5U·鼠 -1)、罗格列酮并用小剂量胰岛素的降糖作用 ;大鼠尾静脉注射卡介苗 (10mg·鼠 -1)制备免疫性胰岛素抵抗模型 ,观察罗格列酮对模型的葡萄糖输注速率的回升作用。结果　罗格列酮 1,3 ,10 μmol·kg-13个剂量组连续灌胃给药 8d ,均未能降低正常大鼠血糖 ,也未能降低链佐菌素所致糖尿病大鼠血糖 ;但在并用小剂量胰岛素条件下 ,罗格列酮 3 ,10 μmol·kg-1连续灌胃给药 8d ,能降低链佐菌素所致糖尿病大鼠血糖 ;罗格列酮 10 μmol·kg-1连续灌胃给药 8d后 ,用正糖钳技术检测 ,免疫性胰岛素抵抗模型亚极高和极高胰岛素状态下的葡萄糖输注速率均得到回升。结论　罗格列酮具有胰岛素增敏作用和胰岛素抵抗改善作用

Insulin sensitizing effect and insulin resistance ameliorating effect of rosiglitazone

AIM To observe the insulin sensitizing effect and insulin resistance ameliorating effect of rosiglitazone. METHODS On the IDDM model prepared by the intravenous injection of streptozotocin (50 mg·kg -1 ), the decrease of blood glucose of only rosiglitazone, only a low dose of insulin (2 5 U·rat -1 , sc), rosiglitazone plus a low dose of insulin on the models were calculated; On the immune model of insulin resistance prepared by the intravenous injection of bacillus calmette guerin (BCG, 10 mg·kg -1 ), the increase of glucose infusion rate (GIR) of rosiglitazone on the model was measured. RESULTS At three doses of 1、3、10 μmol·kg -1 ( po on successive 8 days), rosiglitazone decreased the blood glucose values neither of the normal rats nor of the diabetes rats induced by streptozotocin. However, rosiglitazone, at the doses of 3、10 μmol·kg -1 ( po on successive 8 days) plus a dose of insulin (2 5 U·rat -1 ·d -1 , sc on successive 8 days), decreased the blood glucose values of the diabetes rats induced by streptozotocin. Rosiglitazone, at a dose of 10 μmol·kg -1 ( po on successive 8 days) increased the GIR (glucose infusion rate) of the model, determined by both submaximal hyperinsulinemic euglycemic clamp and maximal hyperinsulinemic euglycemic clamp. CONCLUSIONS Rosiglitazone possesses the insulin sensitizing effect and insulin resistance amelioration effect.