| 血红素加氧酶-1与肾脏损伤 |
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| 引用本文： | 麦海星,陈立军,陈彪,游华,张旭.血红素加氧酶-1与肾脏损伤[J].解放军医学杂志,2012,37(2):156-159. |
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| 作者姓名： | 麦海星 陈立军 陈彪 游华 张旭 |
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| 作者单位： | 麦海星 (100071北京,解放军307医院泌尿外科) ； 陈立军 (100071北京,解放军307医院泌尿外科) ； 陈彪 (100071北京,解放军307医院泌尿外科) ； 游华 (100071北京,解放军307医院淋巴瘤及头颈部肿瘤科) ； 张旭 (100853北京,解放军总医院泌尿外科) ； |
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| 摘 要： | 血红素加氧酶-1(HO-1)作为哺乳动物降解血红素的主要途径之一,其主要降解产物——一氧化碳(CO)、自由铁(Fe2+)和胆绿素——在促进细胞生存、细胞内物质循环及免疫调节中具有重要作用。既往研究提示血红素-HO-1通路是决定急性肾损伤(AKI)易感性及严重性的重要内在因素。诱导HO-1表达能够减轻肾脏缺血-再灌注损伤(IRI)的严重程度,而抑制HO-1的表达会加重IRI。本文综述了国内外有关HO-1在AKI诱导保护机制方面的最新研究进展,以便深入认识HO-1在AKI治疗中的作用。
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| 关 键 词： | 血红素加氧酶-1 肾疾病 再灌注损伤 |
Kidney injury and heme oxygenase-1 |
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| MAI Hai-xing,CHEN Li-jun,CHEN Biao,YOU Hua,ZHANG Xu.Kidney injury and heme oxygenase-1[J].Medical Journal of Chinese People's Liberation Army,2012,37(2):156-159. |
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| Authors: | MAI Hai-xing CHEN Li-jun CHEN Biao YOU Hua ZHANG Xu |
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| Affiliation: | 1Department of Urology,2Department of Lymphoma and Head and Neck Oncology,307 Hospital of PLA,Beijing 100071,China 3Department of Urology,General Hospital of PLA,Beijing 100853,China |
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| Abstract: | Heme oxygenase-1(HO-1) is one of the main pathways to degrade heme in mammals,and the main degradation products are free iron(Fe2+),carbon monoxide(CO),and bilirubin.Heme plays an important role in promoting cell survival,circulation of intracellular substrates,and immune regulation.Previous studies suggest that the heme-HO-1 pathway is an important internal factor in determining the susceptibility and severity of acute kidney injury(AKI).The induction of HO-1 expression can attenuate the severity of renal ischemia-reperfusion injury(IRI),and the inhibition of HO-1 expression will accentuate the injury of IRI.The present article summarizes the latest advances in research into HO-1 regarding the protective mechanism on AKI conducted abroad and at home to learn more information about HO-1 in the treatment of AKI. |
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| Keywords: | heme oxygenase-1 kidney diseases reperfusion injury |
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