人参二醇皂甙对失血性休克犬单胺类递质和单胺氧化酶的影响

42只杂种犬按体重随机分为失血性休克组(HS)、人参二醇皂甙预治疗组(HSG)、地塞米松预治疗组(HSD)。实验过程中通过调整血容量维持平均动脉压至5.3kpa(40mmHg),定期采血测血消NE、DA、5-HT、5-HIAA及MAO的含量。结果表明:人参二醇皂甙不仅能阴止休克时NE、DA含量的增加,还能增加麻醉后NE的含量。而地塞米松只能阻止休克时NE含量的增加。人参二醇皂甙对5-HT的影响与地塞米松相同,失血3小时前5-HT含量逐渐增高,而于第4、5小时下降,提示二者均可抑制休克晚期血小板对5-HT的释放。单胺氧化酶的含量变化各组无显著差异。

Effect of panaxadiol saponins on the monoaminemediator and MAO in hemorrhagic shock dogs

Fourty two hybrid dogs were randomly divided into hemorrhagic shock group (HS), panaxadiol saponin pretreated group(HSG) and dexamethasone pretreated group(HSD). The mean arterial pressure was kept around 5.33KPa(40mmHg)by bleeding and infusion. Arterial blood was collected and examined for serum NE, DA, 5-HT, 5-HI-AA and MAO. The results showed that the panaxadiol saponins not only could prevent hemorrhagic shock from an increased in NE, DA, but also increase contents of NE after anaesthesia; dexamethasone could only prevent hemorrhagic shock from an increase in contents of NE. The effects of panaxadiol saponins and dexamethasone on 5-HT were similar, the contents in serum 5-HT increased gradually three hours posthemorrhage, then decreased at the 4th, 5th hour of posthemorrhage. The results indicate that the release of 5-HT from platelet can be inhibited by panaxadiol saponins and dexamethasone in the 4th hour of posthemorrhage. The changes of MAO are similar among three groups.