| 脑出血患者一氧化氮、一氧化氮合酶的变化及临床意义 |
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| 引用本文： | 肖泉,庞刚,钟书,唐秀文,曾敬初,叶劲,刘若平.脑出血患者一氧化氮、一氧化氮合酶的变化及临床意义[J].中华实验外科杂志,2003,20(8):701-703. |
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| 作者姓名： | 肖泉 庞刚 钟书 唐秀文 曾敬初 叶劲 刘若平 |
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| 作者单位： | 530021,南宁,广西壮族自治区人民医院神经外科 |
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| 基金项目： | 广西壮族自治区科技厅资助项目(桂科攻0055001) |
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| 摘 要： | 目的 探讨一氧化氮(NO)、一氧化氮合酶(NOS)与脑出血的关系。方法 测定76例脑出血患者及66例健康人血浆NO、NOS含量，分析上述指标在出血后3个时期的变化以及与患者颅内血肿量、是否合并蛛网膜下腔出血和临床预后的关系。结果 与对照组相比，脑出血1～3d组NO、NOS含量明显高于4～7d组、14d组和对照组，NO、NOS变化与颅内血肿量和／或合并蛛网膜下腔出血有一定关系。结论 NO、NOS参与了脑出血病理生理过程，其变化对病情的预后有一定的意义。
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| 关 键 词： | 脑出血 一氧化氮 一氧化氮合酶 颅内血肿 蛛网膜下腔出血 临床意义 |
| 修稿时间： | 2003年1月11日 |
Changes in serum nitric oxide, nitric oxide synthase of cerebral hemorrhage |
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| XIAO Quan,PANG Gang,ZHONG Shu,et al..Changes in serum nitric oxide, nitric oxide synthase of cerebral hemorrhage[J].Chinese Journal of Experimental Surgery,2003,20(8):701-703. |
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| Authors: | XIAO Quan PANG Gang ZHONG Shu |
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| Affiliation: | XIAO Quan,PANG Gang,ZHONG Shu,et al. Department of Neurosurgery,The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China |
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| Abstract: | Objective To study the changes in serum nitric oxide (NO), nitric oxide synthase
(NOS) of cerebral hemorrhage. Methods Serum NO and NOS contents in 76 cases of cerebral hemor-
rhage and 66 healthy volunteers were determined. The changes in NO and NOS at three time phases after
hemorrhage and their correlation with the degree of cerebral hemorrhage, subarachnoid hemorrhage
(SAH) and clinical prognosis were analyzed. Results The serum NO and NOS contents in 1-3 day group
were significantly higher than in 4-7 day group, 14--day group and control group. The changes of serum
NO and NOS has some correlation with the degree of cerebral hemorrhage and SAH. Conclusion NO
andNOS are involved in the pathophysiology of cerebral hemorrhage and their changes are related with
the clinical prognosis of the disease. |
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| Keywords: | Cerebral hemorrhage Nitric oxide Nitric oxide synthase |
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