Metastatic breast cancer from gastric and ovarian cancer,mimicking inflammatory breast cancer: report of two cases |
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Authors: | Tomoi Sato Ichiro Muto Mae Fushiki Miki Hasegawa Masaki Hasegawa Takeshi Sakai Masao Sekiya |
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Affiliation: | (1) Department of Surgery, Niigata Prefectural Central Hospital, 205 Shinnan-cho, Joetsu, Niigata 943-0192, Japan;(2) Department of Pathology, Niigata Prefectural Central Hospital, 205 Shinnan-cho, Joetsu, Niigata 943-0192, Japan |
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Abstract: | Breast metastases from extra-mammary malignancies, especially those mimicking primary inflammatory breast carcinoma, are extremely
rare. We report here two cases of inflammatory breast metastases from gastric or ovarian cancer. Both patients, who had prior
advanced malignant disease, presented with unilateral breast redness and swelling with peau d’orange sign, resembling primary
inflammatory breast cancer or acute mastitis. Breast biopsy revealed poorly differentiated adenocarcinoma with signet-ring
cells or clear cell carcinoma in the lymphatic vessels and the parenchyma without an in situ lesion, similar to primary lesions
of the stomach or ovary, respectively. Immunohistochemical staining for estrogen receptor, progesterone receptor, and gross
cystic disease fluid protein 15 was of value for correct diagnosis. Since breast metastasis is a sign of poor prognosis of
the primary malignant disease, the possibility of breast metastasis should be considered in appropriate patients to preclude
unnecessary major surgery. |
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Keywords: | Breast cancer Gastric cancer Ovarian cancer |
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