老年人乙状结肠癌腹腔镜手术对细胞免疫功能的影响

Objective To investigate the effect of laparoscopic colectomy on T Lymphocytic cell subpopulation, NK cell, lnterleukin-2 （IL-2） and interleukin-6（IL-6） in elderly patients with colon cancer. Methods Thirty elderly patients with colon cancer undergoing eolectomy were randomly divided into laparoscopic colectomy group （groupⅠ n = 15）and open colectomy group（groupⅡ n = 15）. Blood samples were taken before operation and 4 h,8 h,24 h,48 h,168 h after the operation for the determination of T Lymphocytic cell subpopulation （CD3, CD4,CD8,CD4/CD8）, NK cell, Interleukin-2 （IL-2）and Interleukin-6（IL-6）. Results Before operation, there was no significant difference of CD3,CD4,CD8 ,CD4/CD8, NK cell, IL-2 and IL-6 between the two groups. The level of CD3, CD4 and Nk cells were all decreased at postoperative 4 h ,8 h,24 h,48 h in group Ⅰ as compared with baseline value, and were lower than those of basehne value in group Ⅱ. Compared with groupⅠ, the level of CD3 in group Ⅱ was increased at postoperative 8 h,24 h ,48 h, and the level of CD4 was also increased at postoperative 4 h,24 h ,48 h , meanwhile the concentration of NK cell was remarkably high. Compared with baseline value , IL-2 was decreased at postoperative 4 h ,8 h,24 h,48 h in group Ⅰ ,while IL-6 was increased significantly after operation, the tendency was the same in group Ⅱ. IL-2 in group Ⅰwas lower than that of group Ⅱ at postoperative 4 h ,8 h,24 h,48 h, while IL-6 in group Ⅰ was remarkably higher than that of group Ⅱ at postoperative 4 h ,8 h,24 h,48 h. Conclusion The depression of immunological function in elderly patients undergoing laparoscopic colectomy is less than that of open surgery. This might be benificial to the patients with colectomy.

The change of immunological function in elderly patients undergoing laparoscopic colectomy