| AdipostatinA的简易合成 |
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| 引用本文： | 杨丽娟,武利强,杨春广.AdipostatinA的简易合成[J].河南职工医学院学报,2008,20(5):429-431. |
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| 作者姓名： | 杨丽娟 武利强 杨春广 |
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| 作者单位： | 新乡医学院药学院,河南,新乡,453003 |
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| 摘 要： | 目的用简易方法合成AdipostatinA。方法以3，5-二甲氧基溴苯为原料，经金属化、偶联、脱甲基化反应制得AdipostatinA。结果成功地合成了AdipostatinA，总收率为64％。目标化合物的结构经核磁共振氢谱及元素分析确证。结论本法合成步骤短，反应条件温和，收率较高。
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| 关 键 词： | Adipostatin A 3 5-二甲氧基溴苯 偶联 合成 |
Facile Total Synthesis of Adipostatin A |
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| YANG Li-juan,WU Li-qiang,YANG Chun-guang.Facile Total Synthesis of Adipostatin A[J].Journal of Henan Medical College For Staff and Workers,2008,20(5):429-431. |
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| Authors: | YANG Li-juan WU Li-qiang YANG Chun-guang |
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| Affiliation: | YANG Li-juan,WU Li-qiang,YANG Chun-guang (School of Pharmacy,Xinxiang Medical College,Xinxiang Henan 453003,China) |
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| Abstract: | Objective To synthesize Adipostatin A by an improved synthetic method.Methods Adipostatin A was synthesized from 3,5-dimethoxybromobenzene through three steps: metallation with Mg,coupling,with(Z)-1-bromo-8-pentadecane in the presence of Li2CuCl4-THF,demethylation with MeMgI.Results Adipostatin A was synthesized successfully in the total yield of 64%.The structure of the target compound was confirmed by 1H-NMR and elemental analysis.Conclusion This synthetic technique is simple,convenient and effective. |
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| Keywords: | Adipostatin A |
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