| Dmrt基因在脊椎动物性别决定与分化中的研究进展 |
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| 引用本文： | 雷蕾,李忻怡,张育辉.Dmrt基因在脊椎动物性别决定与分化中的研究进展[J].中国组织化学与细胞化学杂志,2013,22(3):269-276. |
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| 作者姓名： | 雷蕾 李忻怡 张育辉 |
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| 作者单位： | 雷蕾 (陕西师范大学生命科学学院,西安,710062)； 李忻怡 (陕西师范大学生命科学学院,西安,710062)； 张育辉 (陕西师范大学生命科学学院,西安,710062)； |
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| 基金项目： | 国家自然科学基金资助(项目编号：30770243),中央高校基本科研项目资助(项目编号：200902039) |
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| 摘 要： |
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| 关 键 词： | Dmrt基因家族 DM保守域 Dmrt基因表达 脊椎动物 遗传性别决定通路 |
Research Progress in Dmrt Genes in Sex Determination and Differentiation of Vertebrates |
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| Lei Lei,Li Xinyi,Zhang Yuhui.Research Progress in Dmrt Genes in Sex Determination and Differentiation of Vertebrates[J].Chinese Journal of Histochemistry and Cytochemistry,2013,22(3):269-276. |
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| Authors: | Lei Lei Li Xinyi Zhang Yuhui |
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| Affiliation: | (College of Life Sciences, Shaanxi Normal University, Xi＇an 710062, China) |
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| Abstract: | Dmrt is a gene family in vertebrates, which are homologous genes with Doublesex inDrosophila melanogaster and Matt3 in Caenorhabditis elegans. The characteristics of genes and proteins of Dmrt members were expounded in this review respectively. Analysis of the expression of the development in various vertebrates of showed the Dmrt genes are mainly involved in sex determination and gonad differentiation, and also associated with the development of certain non gonadal tissues and organs： Dmrt is mainly involved in testis differentiation, but sometimes also relevant to ovarian development; Dmrt2 is mainly involved in somitogenesis, differentiation and formation of asymmetric organs; Draft3, 4, 5 can jointly or sequentially regulate the development of olfactory organs and brain;Dmrt7 is required for male gametogenesis; Draft8 isa male-biased expressiongene. Dmrt7 plays different roles in the genetic sex de termination pathway among various vertebrates, varying in its position and functional locus. |
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| Keywords: | Drnrt gene family DM conserved domain Dmrt genes expression Vertebrates Genetic sex determination pathway |
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