树豆脂溶性部位对糖尿病和肥胖小鼠骨密度及血脂水平的影响

目的探讨树豆脂溶性部位(SDE)对糖尿病和肥胖小鼠骨密度及血脂水平的影响。方法 db/db先天糖尿病小鼠和ob/ob先天肥胖小鼠连续8周灌服SDE后,进行骨密度、血清碱性磷酸酶(ALP)、血钙(Ca2+)及血脂水平测定。结果与灌服溶剂空白的模型组小鼠相比,(1)灌服SDE的db/db和ob/ob小鼠胫骨骨密度明显增加(P<0.05),血清ALP水平明显下降(P<0.01),但血钙水平无明显改变;(2)灌服SDE的db/db小鼠血脂水平无明显变化,灌服SDE的ob/ob小鼠血清甘油三酯(TG)水平明显下降(P<0.05),血清总胆固醇(TC)和血清低密度脂蛋白胆固醇(LDL-C)水平明显下降(P<0.01)。结论 SDE能提高糖尿病和肥胖小鼠骨密度,并能改善肥胖小鼠的血脂代谢。

Effects of hydrophobic fraction of Cajanus cajan (L.) Millspaugh on bone density and blood lipid level in obese and diabetic mice

Aim To investigate the effect of hydrophobic fraction of Cajanus cajan(L.) Millspaugh(SDE) on bone density and blood lipid level in diabetic and obese mice.Methods The db/db congenital diabetic mice and ob/ob congenital obese mice were orally administered with SDE for 8 weeks,bone density as well as serum TG,TC,LDL-C,HDL-C,ALP and Ca2+ were measured.Results Compared to mice treated with vehicle,(1) SDE-treated db/db and ob/ob mice had greater bone density(P<0.05) and lower serum ALP level(P<0.01),with serum Ca2+ level relatively unchanged;(2) SDE-treated db/db mice had relatively unchanged blood lipid level,but SDE-treated ob/ob mice had significantly lower levels of TG(P<0.05),TC(P<0.01) and LDL-C(P<0.01).Conclusion SDE increased bone density in diabetic and obese mice,and improved lipid metabolism in obese mice.