海洛因依赖者脑灰质体积的VBM研究

目的探讨海洛因依赖对大脑灰质结构的作用,分析吸食海洛因总时间、吸食海洛因总量、每日吸食海洛因量等因素对脑灰质体积产生的影响。资料与方法采用MRI对17例海洛因依赖者和15名健康受试者行3D结构像扫描,所得数据用基于体素的形态学分析(voxel based morphometry,VBM)方法分析脑灰质体积,并比较两组之间的体积差异;分析脑灰质体积与吸食海洛因总时间、吸食海洛因总量、每日吸食海洛因量之间的相关关系。结果与健康被试者相比,海洛因依赖者右侧眶额回、中央前回、左侧岛叶、扣带回、枕叶舌回灰质体积减少(P<0.005);控制年龄、受教育程度、每日吸烟量后,脑灰质体积变化与使用海洛因总时间、海洛因总量、每日吸食海洛因量之间无显著相关关系。结论长期吸食海洛因导致脑灰质结构损害,主要涉及认知控制、情感、视觉控制等相关脑区。

Voxel Based Morphometry Study of Cerebral Gray Matter Volume in Patients With Heroin Dependence

Objective To investigate the effect of heroin on cerebral gray structure in patients with heroin dependence.Materials and Methods Seventeen heroin dependent patients and 15 normal volunteers performed 3D structural MR examination.The cerebral grey matter volume was measured by voxel based morphometry(VBM).The differences of cerebral grey matter volume between two groups were compared by two sample t-test.Partial correlation analysis was to measure the relativity between grey matter volume and the duration of heroin use,the total dose of heroin use as well as the everyday dose of heroin.Results Compared with the control group,the cerebral gray matter volume in heroin dependent group had a significant decrease(P<0.005)in the right orbital frontal gyrus,right precentral gyrus,left insular,left cingulate gyrus and left lingual gyrus.Partial correlation analysis,which controlled for age,education and nicotine use factors,showed that the duration of heroin use,the total dose of heroin use and the everyday dose of heroin had no significant correlated with the grey matter volume in heroin dependent individuals.Conclusion The gray matter was injured in the brains of heroin dependent patients,mainly involving the brain regions associate with cognition,affection,visual control and so on.