Epithelioid angiomyolipoma of the kidney |
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Authors: | MUSTAFA FUAT ACIKALIN NILÜFER TEL ÜLKÜ ÖNER ÖZGÜL PASAOGLU TURGUT DÖNMEZ |
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Affiliation: | Osmangazi University Medical Faculty, Department of Pathology, Eskisehir, Turkey. acikalin@ogu.edu.tr |
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Abstract: | Epithelioid angiomyolipoma is a recently recognized variant of angiomyolipoma, which is characterized by the presence of polygonal cells with densely eosinophilic cytoplasm and varying degrees of nuclear atypia. Only a relatively small number of cases of epithelioid angiomyolipoma of the kidney have been reported in the literature. We report a case of epithelioid angiomyolipoma of the kidney that occurred in a 38-year-old woman. The tumor was composed of diffuse sheets of epithelioid cells, adipocytes and only scattered thick-walled blood vessels. The epithelioid cells had pleomorphic and hyperchromatic nuclei with densely eosinophilic cytoplasm. Hemorrhage, necrotic foci and clusters of foamy macrophages were present. HMB-45, CD117 (c-kit) and CD68 were detected in the epithelioid cells. There was no expression of cytokeratin, epithelial membrane antigen or desmin. The patient showed no evidence of recurrence or metastatic disease 9 months after nephrectomy. |
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Keywords: | epithelioid cells immunohistochemistry renal tumor |
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