Molecular detection of Orientia tsutsugamushi strains circulating in Nagaland |
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| Authors: | Siraj A Khan Jahnabi Saikia Trishna Bora Vinotsole Khamo Manju Rahi |
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| Affiliation: | 1. Medical Entomology, Arbovirology and Rickettsial Disease Division, Indian Council of Medical Research (ICMR)-Regional Medical Research Centre (RMRC), Northeast Region, Dibrugarh, 786010, Assam, India;2. Naga Hospital Authority, Kohima, Nagaland, India;3. Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India;1. Department of Microbiology, Jawaharlal Nehru Medical College & Hospital, Ajmer (Rajasthan), India;2. Department of Medical Microbiology, Postgraduate Institution of Medical Education & Research (PGIMER), Chandigarh, India;3. Department of Microbiology, Govt. Medical College & Hospital, Chandigarh, India;4. Department of Microbiology, Shri Ramachandra Institute of Higher Education & Research Institute, Chennai, India;1. The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India;2. Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India;1. Department of Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;2. Department of Renal Transplant Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India;3. Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;1. Infectious Diseases, Rajiv Gandhi Cancer Institute, New Delhi, India;2. Microbiology, Rajiv Gandhi Cancer Institute, New Delhi, India;3. Hematology, Rajiv Gandhi Cancer Institute, New Delhi, India;4. Medical Oncology, Rajiv Gandhi Cancer Institute, New Delhi, India;1. Department of Microbiology, Sher- I- Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India;2. Department of General Medicine, Sher- I- Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India;1. Department of Infectious Diseases and Clinical Microbiology, Izmir Bakircay University Ci?li E?itim ve Ara?t?rma Hastanesi, Izmir, Turkey;2. Department of Medical Microbiology, Izmir Chest Diseases and Chest Surgery Training Hospital, Izmir, Turkey;3. Department of Chest Diseases, Izmir Chest Diseases and Chest Surgery Training Hospital, Izmir, Turkey |
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| Abstract: | The antigenic heterogeneity of Orientia in India is still unknown in many disease endemic areas. The present study aims to characterize the strains of O. tsutsugamushi circulating in Nagaland, Northeast India. Two patients clinically diagnosed with ST and hospitalized in Mon district hospital, Nagaland were identified from whom eschar tissues were collected. Both patients demonstrated antibodies against O. tsutsugamushi along with positive PCR amplification for 56 ?kDa gene. The prototype strain TA763 shared 90.4% homology with the sequences. Both the sequences formed a distinctive cluster demonstrating 100% similarity with strains identified from Thailand, Vietnam, China and southern parts of India. |
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| Keywords: | Scrub typhus Eschar Nagaland 56 ?kDa TA763 |
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