新疆地区普通人群中人疱疹病毒8型IgG抗体的调查 …

目的 了解卡波西肉瘤（Ｋａｐｏｓｉ’ｓ ｓａｒｃｏｍｏｎ，ＫＳ）在新疆的普通人群中是否也有较高的流行情况。方法 自新疆的南部及北部地区共采集血清样本１０７１份，其中包括维吾尔（维）族、柯尔克孜（柯）族、哈萨克（哈）族和汉族。以含人疱疹病毒８型（ＨＨＶ－８０的ＢＣＢＬ－１细胞为抗原，通过免疫荧光法检测ＨＶ－８Ｉｇ抗体阳性率最高为４８％、维族次之为３０．４％，哈族为１２．５％，汉族为１６．９％，当血清

Antibody to human herpesvirus type-8 in the general populations of Xinjiang Autonomous Region(A.R.)

OBJECTIVE: Kaposi 's sarcoma (KS) does not rarely occur in Xinjiang A. R. Much of the evidence show that human herpes virus-8 (HHV-8) is associated with KS, and the different incidence of classic KS among different countries reflects the different prevalence in general populations. The aim of this study was to know whether the prevalence of HHV-8 is higher in general populations of Xinjiang than the other places of the country. METHODS: We used BCBL-1 cell line as antigen and collected 1071 serum sample of different nationalities (Uighur, Khalkhas, Kazak and Han nationality) from south and north regions of Xinjiang A. R. for detection of HHV-8 IgG antibody by IFA. RESULTS: The results showed that HHV-8 IgG antibody positive rate in Khalkhas was 48% (96/200), Uighur 30.4%(62/204), Kazak 12.5% (25/200) and Han 16.9% (79/467). While sera were diluted in 1:20, the positive rate in Khalkhas still was as high as 30.5% (61/200). In addition, the positive rate of HHV-8 IgG antibody in minorities in the same native area all were higher than Han except Kazak nationality. CONCLUSIONS: These data illustrated that the prevalence of HHV-8 IgG antibody in general populations of different nationality was different, Khalkhas and Uighur were higher than Kazak and Han. Most of the KS cases were reported from Uighur nationality, but no case was reported from Khalkhas thought a highest HHV-8 IgG antibody detection rate (48%) there was demonstrated. The reason for it would be further studied.