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| 肾脏损伤指标在粮食有机污染物潜在毒性评价中的应用 | |
| 引用本文： | 高红霞,刘英莉,关维俊,邢桂芝,张庆娟,王秀英,范建军.肾脏损伤指标在粮食有机污染物潜在毒性评价中的应用[J].现代预防医学,2011,38(19):3896-3897. |
| 作者姓名： | 高红霞 刘英莉 关维俊 邢桂芝 张庆娟 王秀英 范建军 |
| 作者单位： | 1. 河北联合大学河北省煤矿卫生与安全实验室/公共卫生学院,唐山,063000 2. 唐山市工人医院 3. 唐山市疾病预防控制中心 4. 迁安市人民医院 |
| 基金项目： | 河北省教育厅科学研究计划项目，河北省卫生厅科学研究重点项目计划项目 |
| 摘 要： | 目的]利用小鼠的肾功能指标和氧化损伤指标反映粮食有机污染物的潜在毒性。方法]选取某污灌农田出产的玉米为研究对象(下称"污灌区"),地下水灌溉农田出产的玉米为对照(下称"对照区"),采用超声振荡法提取玉米中的有机污染物,对小鼠灌胃法染毒,共分为5组:对照组(用二甲亚砜染毒),对照区低剂量组、对照区高剂量组、污灌区低剂量组、污灌区高剂量组,每日染毒1次,连续染毒2周。测定肾功能指标:尿酸(UA)、肌肝(Cr)、尿素氮(UN)。肾组织的氧化损伤指标:总超氧化物歧化酶(T-SOD),丙二醛(MDA),谷胱甘肽过氧化物酶(GSH-PX)。结果]与对照组比较,污灌区高剂量组的UN增高,污灌区各组肾组织的T-SOD、GSH-PX活性均降低(P﹤0.05)。与对照区相同染毒剂量组比,污灌区各剂量组T-SOD活性降低(P﹤0.05)。结论]该污灌区玉米中有机污染物可导致小鼠肾脏损伤。 |
| 关 键 词： | 污灌 农产品 有机污染物 小鼠 肾脏损伤 |
APPLICATION OF RENAL DAMAGE INDICES IN ASSESSMENT OF TOXICITY OF ORGANIC POLLUTANTS OF GRAIN |
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| GAO Hong-xia,LIU Ying-li,GUAN Wei-jun,et al..APPLICATION OF RENAL DAMAGE INDICES IN ASSESSMENT OF TOXICITY OF ORGANIC POLLUTANTS OF GRAIN[J].Modern Preventive Medicine,2011,38(19):3896-3897. | |
| Authors: | GAO Hong-xia LIU Ying-li GUAN Wei-jun |
| Affiliation: | GAO Hong-xia,LIU Ying-li,GUAN Wei-jun,et al.(Key Laboratory of Occupational Health and Safety for Coal Industry of Hebei Province,Department of Preventive Medicine,Hebei United University,Tangshan 063000,China) |
| Abstract: | Objective]To study the renal function and oxidative damage of mice,to investigate the potential toxicity of organic pollutants of agricultural products.Methods]Organ extractions were obtained from pollution area and control area.The way to extract organic pollutant was using supersonic method,and gavage method was conducted to the mice(1 once each day for 14 days).According to different contamination doses,the mice were divided to 5 groups.UA,Cr,UN,MDA,T-SOD,GSH-PX were taken.Results]Compared with the co... |
| Keywords: | Sewage irrigation Agricultural products Organic pollutants Mice Renal damage |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
