体重指数及腰臀比与年龄相关白内障关系

目的]探讨中老年人体重指数(BMI)、腰臀比(WHR)与年龄相关白内障(ARC)的关系。方法]采取以医院为基础的病例对照研究。病例为因视力下降接受手术治疗,术后经病理证实为晶状体混浊的260例ARC患者,对照为因患其他非白内障及其他眼部疾病而入住与病例相同医院的同期患者260例。采用标准调查表对研究对象进行面对面调查,同时对身高、体重、腰围、臀围进行测量,并计算BMI及WHR。采用多元Logistic回归分析对研究对象的BMI、WHR与临床ARC的比值比(OR值)及其95%的可信区间(CI)进行估计。结果]与正常体型者(男性WHR﹤0.9;女性﹤0.88)相比,向心性肥胖者(男性WHR≥0.9;女性及≥0.88)发生ARC的危险性增加(OR值分别为2.105和1.821,95%CI分别为1.796～3.238和1.483～2.845),二者间差异有统计学意义(P﹤0.05)。在调整了年龄和性别后,与正常BMI(18.50～23.99)者相比较,无论是超重(BMI24.0～27.99),还是肥胖(BMI≥28.00),发生ARC的危险性均明显升高(超重者OR=1.624,95%CI:1.025～1.986,P=0.015;肥胖者OR=1.745,95%CI:1.321～2.394,P=0.022),而体重过低者(BMI﹤18.50)发生ARC的危险性亦增加(OR=1.370,95%CI:1.103～1.684,P=0.017)。结论]向心性肥胖是发生ARC的一个重要的危险因素,超重和肥胖的人群,发生ARC的危脸性明显增加,维持正常体重可能是ARC发病的保护因素。

BODY MASS INDEX,WASIT TO HIP RATIO AND THE RISK OF AGE-RELATED CATARACT IN MIDDLE AGED AND ELDERLY MEN

Objective]To explore the association between body mass index(BMI),waist to hip ratio(WHR)and age-related cataract(ARC)risk in middle aged and elderly men.Methods]A hospital-based case-control study was conducted.Cases(n =260)were men surgically due to decreased vision and histologically confirmed with ARC,and controls(n =260)were men admitted to the same hospital for different diseases which not related with age-related eye conditions.Height and weight,waist circumference and hip circumference about study...