建立规律月经周期的青春期McCune-Albright综合征1例及文献复习

目的 分析治疗外周性性早熟各类药物的差异,提高McCune-Albright综合征(MAS)的治疗水平。方法 本文通过回顾1例MAS患儿从幼儿期阴道出血直至青春期建立正常月经周期的诊疗经过,并复习相关文献,分析治疗外周性性早熟的各类药物的利弊,为儿童内分泌专科医生提供诊疗及预后参考。结果 来曲唑从根源上减少雌激素产生,且治疗期间安全性相对较好。结论 来曲唑似乎更适用于治疗MAS患儿的外周性性早熟,但用药过程中需注意系统的随访评估。

McCune-Albright syndrome in adolescence with regular menstrual cycle: A case report and literature review

Objective To analyze the differences of various drugs in treatment of peripheral precocious puberty, and improve the therapeutic level to McCune-Albright syndrome (MAS). Methods In this article, the data of a MAS child from pediatric vaginal bleeding in infancy to regular menstrual cycle in adolescence and the relevant literatures were retrospectively review, the pros and cons of various drugs in treatment of peripheral precocious puberty were analyzed, aiming to provide reference for pediatric endocrinologists. Results Letrozole was relatively safe by reducing endogenous estrogen during treatment. Conclusion Letrozole seems to be more suitable for the treatment of peripheral precocious puberty in MAS children, but follow-up assessments are essential.