维生素B族复合TRP肽和SOD对焦虑性抑郁症C57BL/6小鼠行为学改善的影响

研究了维生素B族复合TRP肽和SOD对焦虑性抑郁症C57BL/6小鼠行为学、血清炎症因子水平的改善作用以及对脑部组织抗氧化活性的影响。维生素B族复合TRP肽和SOD(V_B3V_B6TRP肽SOD=21034;VBPS)高、中、低灌胃剂量分别为260,195,130mg/(kg·d)。研究表明,VBPS能够逆转焦虑性抑郁症小鼠的焦虑样和抑郁样行为、改善其体重增加缓慢的症状,VBPS高剂量组效果显著。VBPS能够降低血清炎症因子(TNF-α、IL-6、IL-1β、IFN-γ)水平和降低大脑组织丙二醛(Malondialdehyde,MDA)的含量和SOD、CAT、NOS抗氧化酶的活性。此外,VBPS可诱导色氨酸—犬尿氨酸(TRP-KYN)代谢下调和犬尿氨酸—烟酰胺腺嘌呤二核苷酸(KYN-NAD^+)代谢上调。综上所述,与焦虑性抑郁症对照组小鼠相比,VBPS治疗的小鼠具有抗炎、抗氧化、逆转焦虑性抑郁症小鼠行为障碍和体重增加缓慢的作用,从而证明膳食补充VBPS具有显著的改善焦虑性抑郁症的作用。

Effects of a formula containing Vitamin B on ameliorates anxious/depression-like behaviors in an C57BL/6 mice model

Investigated effects of vitamin B complex TRP peptides and SOD on the anti-oxidative activity in brain tissue,serum inflammatory factor levels and reverse anxious/depression-like behaviors.Vitamin B complex TRP peptide and SOD(V B3︰V B6︰TRP peptide︰SOD=2︰10︰3︰4;VBPS)high,medium and low gavage doses were 260,195,130 mg/(kg·d),respectively.Studies showed that VBPS could reverse the anxious/depression-like behaviors and the slow body weight gain,with VBPS at a high dose being more effective.VBPS showed to control the effects of serum inflammatory cytokines(TNF-α,IL-6,IL-1βand IFN-γ),decrease malondialdehyde(MDA)levels and increase superoxide dismutase(SOD),catalase(CAT),nitric oxide synthase(NOS)activity.In addition,VBPS induced down-regulation of TRP–KYN metabolism and up-regulation of KYN–NAD+metabolism.In summary,results from animal experiments showed that VBPS had a significant anti-anxious depression effects as evidenced by anti-inflammatory,anti-oxidation,reversed behavioral dysfunctions and bodyweight of mice treated with VBPS compared to the anxious depression control mice.It is proved that consume VBPS diets can induce significant beneficial effects on anxious depression.