伐地那非对急性肺血栓栓塞症家兔的治疗效果研究

目的探讨伐地那非治疗急性肺血栓栓塞症（APTE）的疗效及可行性。方法选用日本大耳纯种家兔36只,随机分为4组,每组9只,分别为空白对照组、APTE模型组、伐地那非低剂量组、伐地那非高剂量组。对家兔进行急性肺血栓栓塞症造模,APTE组无药物干预;伐地那非低剂量组：予伐地那非片1.5 mg/kg治疗;伐地那非高剂量组：予伐地那非片3.0 mg/kg治疗。测定家兔栓塞后各时间点（0 h,1 h,2 h,4 h）的动脉血气、肌钙蛋白（cTnI）、N端前脑钠肽（NT-proBNP）、右室收缩压（RVSP）、平均动脉压（MAP）并比较各组数据。结果 APTE模型组与伐地那非低、高剂量组检验结果差异均具有统计学意义（P〈0.05）;伐地那非低、高剂量组检验结果差异具有统计学意义（P〈0.05）。结论伐地那非可改善急性肺血栓栓塞家兔的动脉血气、NT-proBNP、cTnI及血流动力学指标,对肺栓塞有一定的治疗效果。

Therapic effect research on vardenafil for acute pulmonary thromboem- bolism rabbits

Objective To investigate the therapic effect and feasibility of vardenafil in the treatment of acute pul- monary thromboembolism（APTE）. Methods A total of 36 Japan large ear purebred rabbits were randomly divided into 4 groups, respectively for the control group, the APTE model group, the low-dose vardenafil group, the high-dose var- denafil group, and each group had 9 rabbits. The APTE model of rabbits were made. The APTE model group were giv- en non-drug intervention, while the low-dose vardenafil group were given 1.5 mg/kg vardenafil treatment, and the high-dose vardenafil group were given 3.0 mg/kg vardenafil treatment. The arterial blood gas, cardiac troponin I（cTnI）, N-terminal pro B-type natriuretic peptide （NT-proBNP）, right ventricular systolic pressure （RVSP）, mean arterial pres- sure（MAP） of rabbits at 0 h, 1 h, 2 h and 4 h after transarterial chemoembolization were determined and compared. Results The differences were statistically significant in examination results among the APTE model group, the low- dose vardenafil group and the high-dose vardenafil group （P〈0.05）. There were significant differences in examination results between the low-dose vardenafil group and the high-dose vardenafil group （P〈0.05）. Conclusion Vardenafil can im prove the arterial blood gas, NT-proBNP, cTnI and hemodynamics indexes of acute pulmonary thromboembolism rabbits, and has some therapic effect for pulmonary embolism.