IgM抗体诊断早期先天梅毒

我们用梅毒特异性19（s)IgM-TPPA抗体检测方法，对5例常规梅毒血清学方法RPR和TPPA两个试验均阳性的新生儿（其母亲已在怀孕时被确诊为不同病期梅毒）进行了检测。患儿中有3例19（s)IgM-TPPA阳性，另2例阴性。最终确诊3例新生儿为先天梅毒。特异性IgM检测应该作为新生儿和早期无症状先天梅毒确诊的实验诊断方法。加强婚前、孕前及早孕期的梅毒筛查和治疗，对控制先天梅毒的发生有重要意义。

Laboratory diagnosis of early congenital syphilis

Using19(s)IgM-TPPA,5newborns,who were both RPR and TPPA positive and whose mothers were diagnosed with syphilis at different stages,were tested by19(s)IgM-TPPA.Three of them were19(s)IgM-TPPA positive,but the other2were negative.Mothers of the negative newborns were diagnosed and treated at either before or very early pregnancy,while the mothers of the positive ones were diagnosed and treated during mid-or late pregnancy.It is suggested that specific IgM test should be used as confirmatory laboratory diagnostic method for newborns or early asymptomatic congenital syphilis.The re-sults also demonstrated that pre-marital,pre-pregnant or early pregnant screening and treatment of syphilis remain crucial for controlling congenital syphilis.