| 实验性肝细胞癌T1WI成像与铁含量的关系 |
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| 引用本文： | 陈伟,巫北海,丁仕仪,梁智勇,张绍祥.实验性肝细胞癌T1WI成像与铁含量的关系[J].中国医学影像学杂志,2001,9(6):442-446. |
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| 作者姓名： | 陈伟 巫北海 丁仕仪 梁智勇 张绍祥 |
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| 作者单位： | 1. 重庆市第三军医大学西南医院放射科
2. 重庆市第三军医大学西南医院病理科 |
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| 摘 要： | 目的探讨铁含量对肝细胞癌T1WI信号的影响.材料和方法用0.2%DEN(Sigma产品)灌喂Wistar大鼠80只,诱癌成功后行常规SE序列T1WI、T2WI,对照组20只不灌喂DEN,余同实验组.扫描后处死动物取肝组织与肝癌组织作HE、普鲁士蓝染色,并测定组织内水、铁含量.结果肝癌组织与癌周肝组织含水量无差异,肝癌组织中铁含量低于癌周肝组织,但在呈低信号的肝癌内含铁血黄素含量明显高于呈其它信号强度类型的肝组织.结论水含量不是影响肝癌MR表现的主要因素,含铁血黄素是导致肝癌T1WI呈低信号的因素之一.
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| 关 键 词： | 肝细胞癌 MRI 铁含量 |
| 修稿时间： | 2000年9月25日 |
MR Imaging of Hepatocellular Carcinoma in Rats: Correlation of Metal Iron Content and Signal Intensity |
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| Chen Wei,Wu Beihai,Ding Shiyi,Liang Zhiyong,Zhang Shaoxiang.MR Imaging of Hepatocellular Carcinoma in Rats: Correlation of Metal Iron Content and Signal Intensity[J].Chinese Journal of Medical Imaging,2001,9(6):442-446. |
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| Authors: | Chen Wei Wu Beihai Ding Shiyi Liang Zhiyong Zhang Shaoxiang |
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| Abstract: | Purpose: To investigate the relationship between the content of iron and the signal pattern on MR images in hepatocellular carcinoma (HCC). Materials and Methods: Wistar rats (n=80) were examined on MR SE T 1 weighted and T 2 weighted after success of experimental hepatocellular carcinoma induced by 0.2% diethylnitrosamine. After MR examination, rats were killed and the tissues of HCCs identified by pathology, the quantities of water and iron determined. Results: there had no significant difference between HCCs and surrounding hepatic parenchyma of water content, the content of iron in HCCs average lower than surrounding parenchyma but the content of hemosiderin in HCCs with hypointense signal was higher than other pattern. Conclusion: The water content is not the primary factor for HCCs MR apperance, hemosiderin prolongs the T 1 value of HCCs on SE T 1 weighted. |
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| Keywords: | hepatocellular carcinoma magnetic resonance imaging the content of iron |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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