噁唑烷酮类抗菌药物研究进展

抗生素的广泛使用使得细菌的耐药性问题日益严重,新型抗耐药菌药物的研究已成为抗菌药物研究的主要方向。其中,全合成的噁唑烷酮类抗菌药物利奈噁唑酮已成功上市,并取得了良好的临床治疗效果,这促使了对该类化合物更为深入的研究。本文对噁唑烷酮类抗菌剂的作用机制、耐药机制、结构修饰进行综述,并着重介绍了近年来具有优良抗菌活性的噁唑烷酮类潜在药物。

Progress in the research of novel oxazolidinone antibacterial agents

Since the widespread use of antibiotics has led to the severe rising tide of bacterial resistance, the exploration of new antibacterial drugs has become a crucial part in nowadays researches. The success of lin- ezolid--one typical oxazolidinones drug with potent therapeutic effect has become the impetus for oxazolidi- none to be deeply improved upon going forward. The mechanism of action, the mechanism of resistance and the structural modification of oxazolidinone antibacterial drugs were reviewed. Furthermore, the introduction of potential drugs which were found to possess excellent antibacterial activity in recent years was highly emphasized.