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Improved Diagnostic Sensitivity of Bowel Disease of Prematurity on Contrast-Enhanced Ultrasound |
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| Authors: | Jamaal L Benjamin MD PhD Rebecca Dennis DO Stacy White Jr MD David Munson MD Sudha A Anupindi MD Maciej Piskunowicz MD Kassa Darge MD PhD Ami Gokli MD Misun Hwang MD |
| Affiliation: | 1. Department of Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA;2. Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;3. Department of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;4. Department of Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;5. Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Department of Radiology, Medical University of Gdansk, Gdansk, Poland |
| Abstract: | Bowel diseases of prematurity, including necrotizing enterocolitis, are dreaded ailments of neonates. Early diagnosis is difficult, with clinical and radiographic findings often inconclusive. We present a novel use of contrast-enhanced ultrasound in detection of pediatric bowel disease. Early identification of compromised blood flow or an at-risk bowel can be quantitatively detected and monitored. This ability has implications for guidance of emerging therapies, allowing targeting of inflammation. These findings represent an advancement in detection of bowel disease in neonates. |
| Keywords: | bowel disease of prematurity contrast-enhanced ultrasound necrotizing enterocolitis neonate |
