Synthesis, Characterization, and Cytotoxicity Analysis of a Biodegradable Polyurethane |
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| Authors: | S Sarkar P K Singha S Dey M Mohanty B Adhikari |
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| Affiliation: |
a Materials Science Centre, Indian Institute of Technology, Kharagpur, India
b Biotechnology Department, Indian Institute of Technology, Kharagpur, India
c Bio Medical technology wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India |
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| Abstract: | A polyester urethane was synthesized for use in a biodegradable scaffold. The polyurethane was synthesized in a two-step process: first, ester diol was synthesized from lactic acid and polyethylene glycol 400 (PEG 400), then it was polymerized with toluene diisocyanate using dibutyl tin dilaurate (DBTDL) as a catalyst to form a polyester urethane. Polyester urethane has tensile strength of 51-59 MPa and elongation at fracture of 369-439%. FTIR and XRD were used to confirm the formation and structure of the polymer. Hydrolytic degradation was studied in different alkali solutions and in saline water. In order to assess the cellular response of this material, cytotoxicity analysis was carried out against the cell line. |
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| Keywords: | Antibiotic solution Biodegradation Cell count Cell growth Cell line Cell morphology Cytotoxicity Fetal Bovine Serum Hydrolytic degradation Incubation Lactate ester diol Film casting Polyester urethane Tensile strength Trypsinization |
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