| 调心方活性部位对大鼠海马脑片CA1区诱发LTP的影响 |
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| 引用本文： | 乔海法,杨胜,周文霞,张永祥.调心方活性部位对大鼠海马脑片CA1区诱发LTP的影响[J].中国实验方剂学杂志,2005,11(1):31-34. |
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| 作者姓名： | 乔海法 杨胜 周文霞 张永祥 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金重点项目 (39830 4 50 ) |
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| 摘 要： | 目的：研究调心方活性部位A对大鼠海马脑片诱发长时程增强(LTP)效应的影响。方法：采用细胞外微电极记录技术，记录大鼠海马脑片CA1区诱发群峰电位(PS)，然后施以100Hz，100串的强直刺激诱发LTP。结果：调心方活性部位A对大鼠海马脑片正常PS的形状、幅度无影响，提示并不影响海马的基础突触传递。给予强直刺激后，高浓度活性部位A可以明显增大LTP幅度，提示具有促进和维持LTP的作用。结论：调心方活性部位A可能是调心方促进和维持大鼠海马脑片诱发LTP的有效成分之一，对LTP的促进作用也是调心方活性部位A益智作用的机制之一。
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| 关 键 词： | 调心方 长时程增强 海马脑片 |
| 文章编号： | 1005-9903(2005)01-0031-04 |
| 收稿时间： | 2004/3/15 0:00:00 |
| 修稿时间： | 2004年3月15日 |
Effect of Active Fraction of Tiaoxin Recipe on Long-term Potentiation of CA1 in Rat Hippocampal Slices |
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| QIAO Hai-f,YANG Sheng,ZHOU Wen-xi,ZHANG Yong-xiang.Effect of Active Fraction of Tiaoxin Recipe on Long-term Potentiation of CA1 in Rat Hippocampal Slices[J].China Journal of Experimental Traditional Medical Formulae,2005,11(1):31-34. |
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| Authors: | QIAO Hai-f YANG Sheng ZHOU Wen-xi ZHANG Yong-xiang |
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| Affiliation: | Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China |
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| Abstract: | Aim:To investigate the active fraction A(TRX A) of Tiaoxin Recipe(TXR) on long term potentiation(LTP) of CA1 area in the rat hippocampl slices.Methods:LTP in CA1 area of rat hippocampal slices,which was induced by high frequency stimulation(100Hz,100pulses),was recorded with extracellular recording technique.Results:TXR A or TXR showed no effect on baseline synaptic responses.Compared with the slices pre incubated and perfused with decoction free artificial cerebrospinal fluid(ACSF),population spike(PS) amplitude of slices exposed to TXR A or TXR ACSF was significantly increased after high frequency stimulation.Conclusion:TXR A is one of TXR active fractions which facilitate LTP in CA1 area of slices from rat. |
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| Keywords: | Tiaoxin Recipe Long-term potentiation hippocampal slice |
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