|
|||||
|
|
| 小脑顶核电刺激对心肌梗死大鼠脑组织5-羟色胺含量的影响 | |
| 引用本文： | 张润峰,李霞,胡大一,高文根,魏毅东,邢燕.小脑顶核电刺激对心肌梗死大鼠脑组织5-羟色胺含量的影响[J].山西医科大学学报,2011,42(8):613-616. |
| 作者姓名： | 张润峰 李霞 胡大一 高文根 魏毅东 邢燕 |
| 作者单位： | 1. 四川省绵阳市第三人民医院心血管内科,绵阳,621000 2. 复旦大学附属华山医院神经内科 3. 北京大学人民医院心脏中心 4. 同济大学心肺血管中心 |
| 基金项目： | 国家自然科学基金资助项目(30571780); 中国博士后基金资助项目(20100471798); 绵阳市科技局资助科研项目(10S1-1) |
| 摘 要： | 目的通过研究小脑顶核电刺激(FNS)对心肌梗死(MI)大鼠脑组织神经递质5-羟色胺(5-HT)的影响,探讨5-HT在FNS干预心脏性猝死(SCD)中的作用。方法 SD大鼠90只,随机分为3组,每组30只:MI组,仅结扎左冠状动脉前降支(LAD);FNS组,预先FNS 1 h再予以LAD结扎;小脑顶核毁损组,毁损小脑顶核5 d后FNS 1 h,再行LAD结扎;各组又分MI后1,7,21 d三个亚组。另取8只设为假手术组。LAD结扎1,7,21 d后,应用荧光分光光度法测定大鼠脑组织内5-羟色胺含量。结果①LAD结扎1,7 d后,与假手术组比较,MI组和小脑顶核毁损组大鼠脑组织5-HT均明显降低(P<0.05);与MI组比较,FNS组大鼠脑组织5-HT明显增加(P<0.05);小脑顶核毁损组与MI组脑组织5-HT含量比较差异无统计学意义(P>0.05)。②LAD结扎21 d后,各实验组间大鼠脑组织5-HT含量比较无统计学差异。结论 FNS可增加心肌梗死大鼠早期脑组织5-HT含量,并可能通过增加5-HT含量来控制心脏性猝死的发生。 |
| 关 键 词： | 小脑顶核 电刺激 心肌梗死 5-羟色胺 心脏性猝死 |
Effects of fastigial nucleus electrical stimulation on serotonin contents in the brain tissues of rats after myocardial infarction |
|
| ZHANG Run-feng,LI Xia,HU Da-yi,GAO Wen-gen,WEI Yi-dong,XING Yan.Effects of fastigial nucleus electrical stimulation on serotonin contents in the brain tissues of rats after myocardial infarction[J].Journal of Shanxi Medical University,2011,42(8):613-616. | |
| Authors: | ZHANG Run-feng LI Xia HU Da-yi GAO Wen-gen WEI Yi-dong XING Yan |
| Affiliation: | ZHANG Run-feng1,LI Xia2,HU Da-yi3,GAO Wen-gen3,WEI Yi-dong4,XING Yan4(1Dept of Cardiology,Third People's Hospital of Mianyang,Mianyang 621000,China,2Dept of Neurology,Huashan Hospital,Fudan University,3Heart Center,People's Hospital of Beijing University,4Heart,Lung and Blood Vessel Center,Tongji University) |
| Abstract: | Objective To investigate the effects of fastigial nucleus electrical stimulation(FNS)on the serotonin(5-hydroxytryptamine,5-HT) contents in brain tissues of rats after myocardial infarction(MI),and to explore the role of 5-HT in the prevention of sudden cardiac death(SCD) after FNS.Methods Ninety SD rats were randomized into 3 groups with 30 rats in each group:MI group,FNS group and fastigial nucleus lesion group.In MI group,left anterior descending artery of rats was ligated.In FNS group,rats were pretreat... |
| Keywords: | fastigial nucleus electrical stimulation myocardial infarction serotonin(5-HT) sudden cardiac death |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
